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  • Stening, Kent,1968-Linköpings universitet,Linnéuniversitetet,Institutionen för hälso- och vårdvetenskap, HV,Department of Experimental and Clinical Medicine, Division of Cell Biology, Faculty of Health Sciences, Linköping University, Linköping, Sweden; Department of Health and Caring Sciences, Linnaeus University, Kalmar, Sweden,Cellbiologi,Hälsouniversitetet (author)

Hormonal replacement therapy does not affect self-estimated pain or experimental pain responses in post-menopausal women suffering from fibromyalgia: a double-blind, randomized placebo-controlled trial

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • 2010-11-14
  • London :Oxford univesity press,2011
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:lnu-9425
  • https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-9425URI
  • https://doi.org/10.1093/rheumatology/keq348DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-107940URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-141137URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-66851URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Objectives. FM is a condition that preferentially affects women. Sex hormones, and in particular oestrogens, have been shown to affect pain processing and pain sensitivity, and oestrogen deficit has been considered a potentially promoting factor for FM. However, the effects of oestrogen treatment in patients suffering from FM have not been studied. Here, we examined the effect of transdermal oestrogen substitution treatment on experimental as well as self-estimated pain in women suffering from FM.Methods. Twenty-nine post-menopausal women were randomized to either 8 weeks of treatment with transdermal 17β-oestradiol (50 µg/day) or placebo according to a double-blind protocol. A self-estimation of pain, a set of quantitative sensory tests measuring thresholds to temperature, thermal pain, cold pain and pressure pain, and a cold pressor test were performed on three occasions: before treatment, after 8 weeks of treatment and 20 weeks after cessation of treatment.Results. Hormonal replacement treatment significantly increased serum oestradiol levels as expected (P < 0.01). However, no differences in self-estimated pain were seen between treatment and placebo groups, nor were there any differences between the two groups regarding the results of the quantitative sensory tests or the cold pressor test at any of the examined time points.Conclusion. Eight weeks of transdermal oestradiol treatment does not influence perceived pain, pain thresholds or pain tolerance as compared with placebo treatment in post-menopausal women suffering from FM.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Eriksson, OlleLinköpings universitet,Statistik,Filosofiska fakulteten(Swepub:liu)oller83 (author)
  • Henriksson, Karl-GöstaÖstergötlands Läns Landsting,Linköpings universitet,Rehabiliteringsmedicin,Hälsouniversitetet,Smärt- och rehabiliteringscentrum(Swepub:liu)karhe89 (author)
  • Brynhildsen, Jan,1962-Östergötlands Läns Landsting,Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet,Kvinnokliniken i Linköping(Swepub:liu)janbr05 (author)
  • Lindh-Åstrand, LottaÖstergötlands Läns Landsting,Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet,Kvinnokliniken i Linköping(Swepub:liu)lotli58 (author)
  • Berg, GöranÖstergötlands Läns Landsting,Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet,Kvinnokliniken i Linköping(Swepub:liu)gorbe09 (author)
  • Hammar, MatsÖstergötlands Läns Landsting,Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet,Kvinnokliniken i Linköping(Swepub:liu)matha92 (author)
  • Amandusson, ÅsaUppsala universitet,Klinisk neurofysiologi,Uppsala University(Swepub:uu)asaam531 (author)
  • Blomqvist, AndersLinköpings universitet,Cellbiologi,Hälsouniversitetet(Swepub:liu)andbl47 (author)
  • LinnéuniversitetetInstitutionen för hälso- och vårdvetenskap, HV (creator_code:org_t)

Related titles

  • In:RheumatologyLondon : Oxford univesity press50:3, s. 544-5511462-03241462-0332

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