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Qualitative faecal ...
Qualitative faecal immunochemical tests (FITs) for diagnosing colorectal cancer in patients with histories of rectal bleeding in primary care : a cohort study
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- Högberg, Cecilia (författare)
- Umeå universitet,Kardiologi,Umeå University, Sweden
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- Gunnarsson, Ulf (författare)
- Umeå universitet,Kirurgi,Clister,Umeå University, Sweden
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- Cronberg, Olof (författare)
- Lund University,Lunds universitet,Allmänmedicin och samhällsmedicin,Forskargrupper vid Lunds universitet,Family Medicine and Community Medicine,Lund University Research Groups,Region Kronoberg
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- Thulesius, Hans (författare)
- Linnaeus University,Lund University,Lunds universitet,Linnéuniversitetet,Institutionen för medicin och optometri (MEO),Department of Clinical Sciences, Lund University, Malmö, Sweden. Department of R & D, Region Kronoberg, Växjö, Sweden. Department of Medicine and Optometry, Linnaeus University, Kalmar, Sweden.,Innovationsteknik,Institutionen för designvetenskaper,Institutioner vid LTH,Lunds Tekniska Högskola,Allmänmedicin och samhällsmedicin,Forskargrupper vid Lunds universitet,Innovation Engineering,Department of Design Sciences,Departments at LTH,Faculty of Engineering, LTH,Family Medicine and Community Medicine,Lund University Research Groups
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- Lilja, Mikael (författare)
- Umeå universitet,Allmänmedicin,Umeå University, Sweden
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- Jansson, Stefan P. O., 1959- (författare)
- Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,School of Medical Sciences, University Health Care Research Centre, Örebro University, Örebro, Sweden.
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(creator_code:org_t)
- 2020-06-29
- 2020
- Engelska.
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Ingår i: International Journal of Colorectal Disease. - : Springer. - 0179-1958 .- 1432-1262. ; 35, s. 2035-2040
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Background Rectal bleeding is considered an alarm symptom for colorectal cancer (CRC) but it is common and mostly caused by benign conditions. Qualitative faecal immunochemical tests (FITs) for occult blood have been used as diagnostic aids for many years in Sweden when CRC is suspected. The study aimed to evaluate the usefulness of FITs requested by primary care physicians for patients with and without histories of rectal bleeding, in the diagnosis of CRC. Methods Results of all FITs requested in primary care for symptomatic patients in the orebro region during 2015 were retrieved. Data on each patient's history of rectal bleeding was gathered from electronic health records. Patients diagnosed with CRC within 2 years were identified from the Swedish Cancer Register. The analysis focused on three-sample FITs, the customary FIT in Sweden. Results A total of 4232 patients provided three-sample FITs. Information about the presence/absence of rectal bleeding was available for 2027 patients, of which 59 were diagnosed with CRC. For 606 patients with the presence of rectal bleeding, the FIT showed sensitivity 96.2%, specificity 60.2%, positive predictive value 9.8% (95% CI 6.1-13.4) and negative predictive value 99.7% (95% CI 99.2-100) for CRC. For 1421 patients without rectal bleeding, the corresponding figures were 100%, 73.6%, 8.3% (95% CI 5.6-10.9) and 100% (95% CI 99.6-100). Conclusion The diagnostic performance of a qualitative three-sample FIT provided by symptomatic patients in primary care was similar for those with and without a history of rectal bleeding. FITs seem useful for prioritising patients also with rectal bleeding for further investigation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Colorectal neoplasms
- Occult blood
- Faecal immunochemical tests
- Primary health care
- Rectal bleeding
- Medicin
- Medicine
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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