id:"swepub:oai:DiVA.org:lnu-99964"
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- Högberg, CeciliaUmeå University,Umeå universitet,Allmänmedicin,Östersund Hospital, Sweden (författare)
Diagnosing colorectal cancer in primary care : cohort study in Sweden of qualitative faecal immunochemical tests, haemoglobin levels, and platelet counts
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
- London :Royal College of General Practitioners,2020
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:lnu-99964
- https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-99964URI
- https://doi.org/10.3399/bjgp20X713465DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-87220URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-177340URI
- https://lup.lub.lu.se/record/5750ec11-644e-412f-a13b-edbc462a39aaURI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- Funding Agencies:Region Jämtland Härjedalen JLL-758141 JLL-865141Region Kronoberg 2019-0419:2Cancer Research Foundation in Northern Sweden LP17-2168Jämtland's Cancer and Nursing Foundation 146/2018 2131/2017
- This study was supported by unrestricted grants from Region Jämtland Härjedalen (reference numbers: JLL-758141 and JLL-865141), Region Kronoberg (2019-04-19:2), the Cancer Research Foundation in Northern Sweden (LP17-2168), and Jämtland’s Cancer and Nursing Foundation (146/2018 and 2131/2017).
- Background Colorectal cancer (CRC) diagnostics are challenging in primary care and reliable diagnostic aids are desired. Qualitative faecal immunochemical tests (FITs) have been used for suspected CRC in Sweden since the mid-2000s, but evidence regarding their effectiveness is scarce. Anaemia and thrombocytosis are both associated with CRC. Aim To evaluate the usefulness of qualitative FITs requested for symptomatic patients in primary care, atone and combined with findings of anaemia and thrombocytosis, in the diagnosis of CRC. Design and setting A population-based cohort study using electronic health records and data from the Swedish Cancer Register, covering five Swedish regions. Method Patients aged >= 18 years in the five regions who had provided FITs requested by primary care practitioners from 1 January 2015 to 31 December 2015 were identified. FIT and blood-count data were registered and all CRC diagnoses made within 2 years were retrieved. Diagnostic measurements were calculated. Results In total, 15 789 patients provided FITs (four different brands); of these patients, 304 were later diagnosed with CRC. Haemoglobin levels were available for 13 863 patients, and platelet counts for 10 973 patients. Calculated for the different FIT brands only, the sensitivities for CRC were 81.6%-100%; specificities 65.7%-79.5%: positive predictive values 4.7%-8.1%; and negative predictive values 99.5%-100%. Calculated for the finding of either a positive FIT or anaemia, the sensitivities increased to 88.9-100%. Adding thrombocytosis did not further increase the diagnostic performance. Conclusion Qualitative FITs requested in primary care seem to be useful as rule in tests for referral when CRC is suspected. A negative FIT and no anaemia indicate a low risk of CRC.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi hsv//swe
- MEDICAL AND HEALTH SCIENCES Health Sciences Health Care Service and Management, Health Policy and Services and Health Economy hsv//eng
- anaemia
- colorectal neoplasms
- general practice
- occult blood
- thrombocytosis
- Medicin
- Medicine
- anaemia
- colorectal neoplasms
- general practice
- occult blood
- thrombocytosis
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Gunnarsson, UlfUmeå universitet,Kirurgi,Clister,Umeå University, Sweden(Swepub:umu)ulgu0014 (författare)
- Jansson, Stefan P. O.,1959-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,University Health Care Research Centre, Örebro University, Örebro.,Örebro University, Sweden(Swepub:oru)sfjn (författare)
- Thulesius, HansLinnaeus University,Lund University,Lunds universitet,Linnéuniversitetet,Institutionen för medicin och optometri (MEO),Lund university, Sweden,Department of Clinical Sciences, Lund University, Malmö; professor of primary care, Department of Medicine and Optometry, Linnaeus University, Kalmar,Allmänmedicin och samhällsmedicin,Forskargrupper vid Lunds universitet,Family Medicine and Community Medicine,Lund University Research Groups(Swepub:lu)smi-hth (författare)
- Cronberg, OlofLund University,Lunds universitet,Allmänmedicin och samhällsmedicin,Forskargrupper vid Lunds universitet,Family Medicine and Community Medicine,Lund University Research Groups(Swepub:lu)ol8035cr (författare)
- Lilja, MikaelUmeå universitet,Allmänmedicin,Umeå University, Sweden(Swepub:umu)millia03 (författare)
- Umeå universitetAllmänmedicin (creator_code:org_t)
Sammanhörande titlar
- Ingår i:British Journal of General PracticeLondon : Royal College of General Practitioners70:701, s. E843-E8510960-16431478-5242
Internetlänk
- https://doi.org/10.3399/bjgp20X713465Fulltext
- https://umu.diva-portal.org/smash/get/diva2:1507179/FULLTEXT01.pdffulltext:print
- http://dx.doi.org/10.3399/bjgp20X713465FULLTEXT
- https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-99964
- https://doi.org/10.3399/bjgp20X713465
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-87220
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-177340
- https://lup.lub.lu.se/record/5750ec11-644e-412f-a13b-edbc462a39aa
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- British Journal of General Practice (Sök värdpublikationen i LIBRIS)
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- MEDICIN OCH HÄLSOVETENSKAP
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