Simple cardiovascular risk stratification by replacing total serum cholesterol with anthropometric measures: The MORGAM prospective cohort project

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Simple cardiovascular risk stratification by replacing total serum cholesterol with anthropometric measures : The MORGAM prospective cohort project

Rosberg, Victoria (författare): Department of Cardiology, North Zealand Hospital, Hillerød, Denmark

Vishram-Nielsen, Julie KK (författare): Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region of Denmark, Copenhagen, Frederiksberg, Denmark,Finnish National Institute for Health and Welfare

Kristensen, Anna M. Dyrvig (författare): Department of Cardiology, North Zealand Hospital, Hillerød, Denmark,University Hospital Of Strasbourg

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Pareek, Manan (författare): Department of Cardiology, North Zealand Hospital, Hillerød, Denmark; Department of Internal Medicine, Yale New Haven Hospital, Yale University School of Medicine, CT, New Haven, United States

Sehested, Thomas S.G. (författare): Umeå University,UiT The Arctic University of Norway, Tromsø

Nilsson, Peter M. (författare): Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups

Linneberg, Allan (författare): Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region of Denmark, Copenhagen, Frederiksberg, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Palmieri, Luigi (författare): Department of Cardiovascular, Endocrine-metabolic Diseases and Aging, Istituto Superiore di Sanità (ISS), Rome, Italy,Italian National Institute of Health (ISS)

Giampaoli, Simona (författare): Department of Cardiovascular, Endocrine-metabolic Diseases and Aging, Istituto Superiore di Sanità (ISS), Rome, Italy

Donfrancesco, Chiara (författare): Department of Cardiovascular, Endocrine-metabolic Diseases and Aging, Istituto Superiore di Sanità (ISS), Rome, Italy,Italian National Institute of Health (ISS)

Kee, Frank (författare): Centre for Public Health, The Queeńs University of Belfast, Ireland

Mancia, Giuseppe (författare): University of Milano-Bicocca and Policlinico di Monza, Monza, Italy

Cesana, Giancarlo (författare): Research Centre on Public Health, University of Milano Bicocca, Villa Serena, Monza, Italy

Veronesi, Giovanni (författare): Research Centre in Epidemiology and Preventive Medicine (EPIMED), Department of Medicine and Surgery, University of Insubria, Italy

Grassi, Guido (författare): Clinica Medica, University Milano Bicocca, Monza, Italy

Kuulasmaa, Kari (författare): Finnish Institute for Health and Welfare (THL), Helsinki, Finland

Salomaa, Veikko (författare): Finnish Institute for Health and Welfare (THL), Helsinki, Finland,Finnish National Institute for Health and Welfare

Palosaari, Tarja (författare): Finnish Institute for Health and Welfare (THL), Helsinki, Finland,Finnish National Institute for Health and Welfare

Sans, Susana (författare): Catalan Department of Health, Barcelona, Spain

Ferrieres, Jean (författare): Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, Toulouse Cedex 9, France

Dallongeville, Jean (författare): Institut Pasteur de Lille, Lille Cedex, France

Söderberg, Stefan (författare): Umeå universitet,Kardiologi

Moitry, Marie (författare): Department of Epidemiology and Public Health, University of Strasbourg and University Hospital of Strasbourg, Strasbourg, France

Drygas, Wojciech (författare): Department of Epidemiology, CVD Prevention and Health Promotion, National Institute of Cardiology, Warsaw, Poland,Cardinal Wyszynski National Institute of Cardiology

Tamosiunas, Abdonas (författare): Lithuanian University of Health Sciences, Institute of Cardiology, Kaunas, Lithuania

Peters, Annette (författare): Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany

Brenner, Hermann (författare): German Cancer Research Center (DKFZ), Heidelberg, Germany, Network Aging Research (NAR), Heidelberg University, Heidelberg, Germany

Schöttker, Ben (författare): Division of Clinical Epidemiology and Ageing Research, German Cancer Research Center, Heidelberg, Germany

Grimsgaard, Sameline (författare): Department of Community Medicine, UiT the Arctic University of Norway, Tromsø, Norway

Biering-Sørensen, Tor (författare): Department of Cardiology, Herlev and Gentofte Hospital, Copenhagen, Denmark; Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Olsen, Michael H (författare): Department of Internal Medicine, Steno Diabetes Center Zealand, Holbaek Hospital, Holbaek, Denmark; Department of Regional Health Research, University of Southern Denmark, Denmark

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Elsevier, 2022
2022
Engelska.
Ingår i: Preventive Medicine Reports. - : Elsevier. - 2211-3355. ; 26

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://umu.diva-por... (primary) (Raw object); https://doi.org/10.1...; http://dx.doi.org/10... (free); https://urn.kb.se/re...; https://doi.org/10.1...; https://lup.lub.lu.s...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

To assess whether anthropometric measures (body mass index [BMI], waist-hip ratio [WHR], and estimated fat mass [EFM]) are independently associated with major adverse cardiovascular events (MACE), and to assess their added prognostic value compared with serum total-cholesterol. The study population comprised 109,509 individuals (53% men) from the MORGAM-Project, aged 19–97 years, without established cardiovascular disease, and not on antihypertensive treatment. While BMI was reported in all, WHR and EFM were reported in ∼52,000 participants. Prognostic importance of anthropometric measurements and total-cholesterol was evaluated using adjusted Cox proportional-hazards regression, logistic regression, area under the receiver-operating-characteristic curve (AUCROC), and net reclassification improvement (NRI). The primary endpoint was MACE, a composite of stroke, myocardial infarction, or death from coronary heart disease. Age interacted significantly with anthropometric measures and total-cholesterol on MACE (P ≤ 0.003), and therefore age-stratified analyses (<50 versus ≥ 50 years) were performed. BMI, WHR, EFM, and total-cholesterol were independently associated with MACE (P ≤ 0.003) and resulted in significantly positive NRI when added to age, sex, smoking status, and systolic blood pressure. Only total-cholesterol increased discrimination ability (AUCROC difference; P < 0.001). In subjects < 50 years, the prediction model with total-cholesterol was superior to the model including BMI, but not superior to models containing WHR or EFM, while in those ≥ 50 years, the model with total-cholesterol was superior to all models containing anthropometric variables, whether assessed individually or combined. We found a potential role for replacing total-cholesterol with anthropometric measures for MACE-prediction among individuals < 50 years when laboratory measurements are unavailable, but not among those ≥ 50 years.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Adipose tissue
Assessment
risk
Body mass index
Cardiovascular diseases
Cholesterol
Waist-hip ratio
Adipose tissue
Assessment, risk
Body mass index
Cardiovascular diseases
Cholesterol
Waist-hip ratio

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

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Av lärosätet: Umeå universitet; Lunds universitet

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