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- Bitaraf, NazaninLuleå tekniska universitet,Signaler och system (author)
Development of a multifunctional microfluidic system for studies of nerve cell activity during hypoxic and anoxic conditions
- Article/chapterEnglish2009
Publisher, publication year, extent ...
- Berlin :Springer Science+Business Media B.V.2009
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:ltu-40741
- https://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-40741URI
- https://doi.org/10.1007/978-3-642-03887-7_48DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-42401URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Validerad; 2009; 20090403 (nazbit)
- Hemoproteins usually supply cells and tissue with oxygen. A new hemoprotein mainly present in nerve cells called Neuroglobin was recently discovered. Enhanced expression of the protein has been shown to reduce hypoxic neural injury but the mechanism behind this function remains unknown. Methods enabling investigation of the protein in single functional neurons need to be developed. Here, we have studied how the electrical signaling capacity of a neuron was affected by hypoxic environments. Preliminary results show a trend of higher noise-level when a neuron is exposed to hypoxic compared to normoxic surroundings, which implies increased ion-channel activity. The setup used today shows shortages such as reduced control over the oxygen content due to leakage. Therefore, a gas-tight, multifunctional microfluidic system is under development which enables us to study influences of Neuroglobin concentrations on neuronal activity during hypoxia and anoxia. For electrophysiological recordings a patch-clamp micro pipette will be molded into the walls of the microfluidic system. A single biological cell is steered towards the pipette and attached there by means of optical tweezers. The Neuroglobin oxygen binding state will be studied using optical spectroscopy and the neuron environment will be manipulated by applying flows of varying oxygen content through the microfluidic system. This system will constitute a powerful tool in the investigation of the Neuroglobin mechanism of action.
Subject headings and genre
- TEKNIK OCH TEKNOLOGIER Medicinteknik Annan medicinteknik hsv//swe
- ENGINEERING AND TECHNOLOGY Medical Engineering Other Medical Engineering hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
- Hypoxia
- Multifunctional microfluidic system
- Neuroglobin
- Optical spectroscopy
- Optical tweezers
- Patch clamp
- Medical Engineering for Healthcare
- Medicinsk teknik för hälsovård
- Centre - Centre for Biomedical Engineering and Physics (CMTF)
- Centrumbildning - Centrum för medicinsk teknik och fysik (CMTF)
Added entries (persons, corporate bodies, meetings, titles ...)
- Ahmed, AhmedLuleå tekniska universitet(Swepub:ltu)ahmahm (author)
- Druzin, MichaelUmeå universitet,Fysiologi,Department of Integrative Medical Biology, Section for Physiology, Umeå University, 901 87, Umeå, Sweden(Swepub:umu)midr0001 (author)
- Ramser, KerstinLuleå tekniska universitet(Swepub:ltu)ramser (author)
- Luleå tekniska universitetSignaler och system (creator_code:org_t)
Related titles
- In:World Congress on Medical Physics and Biomedical EngineeringBerlin : Springer Science+Business Media B.V., s. 176-179, s. 176-1799783642038976
- In:International Federation for Medical and Biological Engineering Proceedings; 25Berlin : Springer Science+Business Media B.V., s. 176-179, s. 176-179
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