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  • Borges, Ana C.École Polytechnique Fédérale de Lausanne (författare)

Nanofibrillated cellulose composite hydrogel for the replacement of the Nucleus Pulposus

  • Artikel/kapitelEngelska2011

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2011
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:ltu-5725
  • https://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-5725URI
  • https://doi.org/10.1016/j.actbio.2011.05.029DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Validerad; 2011; 20110530 (ysko)
  • The swelling and compressive mechanical behavior as well as the morphology and biocompatibility of composite hydrogels based on Tween® 20 trimethacrylate (T3), N-vinyl-2-pyrrolidone (NVP) and nanofibrillated cellulose (NFC) were assessed in the present study. The chemical structure of T3 was verified by FTIR and 1H NMR and the degree of substitution (DS) was found to be around 3. Swelling ratios of neat hydrogels composed of different concentrations of T3 and NVP were found to range from 1.5 to 5.7 with decreasing concentration of T3. Various concentrations of cellulose nanofibrils (0.2 to 1.6 wt%) were then used to produce composite hydrogels that showed lower swelling ratios than neat ones for a given T3 concentration. Neat and composite hydrogels exhibited typical non-linear response under compression. All composite hydrogels showed an increase in elastic modulus compared to neat hydrogel of about 3 to 8-fold, reaching 18 kPa at 0% strain and 62 kPa at 20% strain for the hydrogel with the highest NFC content. All hydrogels presented a porous and homogeneous structure, with interconnected pore cells of around 100 nm in diameter. The hydrogels are biocompatible. The results of this study demonstrate that composite hydrogels reinforced with NFC may be viable as nucleus pulposus implant due to their adequate swelling ratio that may restore annulus fibrosus loading and their increased mechanical properties that could possibly restore the height of intervertebral discs.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Eyholzer, ChristianLuleå tekniska universitet,Materialvetenskap(Swepub:ltu)chreyh (författare)
  • Duc, FabienÉcole Polytechnique Fédérale de Lausanne (författare)
  • Bourban, Pierre-EtienneÉcole Polytechnique Fédérale de Lausanne (författare)
  • Tingaut, PhilippeSwiss Federal Laboratories for Materials Testing and Research (EMPA) (författare)
  • Zimmermann, TanjaSwiss Federal Laboratories for Materials Testing and Research (EMPA) (författare)
  • Pioletti, Dominique P.École Polytechnique Fédérale de Lausanne (författare)
  • Månson, Jan-Anders E.École Polytechnique Fédérale de Lausanne (författare)
  • École Polytechnique Fédérale de LausanneMaterialvetenskap (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Acta Biomaterialia: Elsevier BV7:9, s. 3412-34211742-70611878-7568

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