id:"swepub:oai:DiVA.org:ltu-68787"
Search: id:"swepub:oai:DiVA.org:ltu-68787" > In vitro-solubility...
- 1 of 1
- Previous record
- Next record
- To hitlist
- AlHayali, AmaniLuleå tekniska universitet,Medicinsk vetenskap (author)
In vitro-solubility and supersaturation behavior of supersaturating drug delivery systems
- BookEnglish2018
Publisher, publication year, extent ...
- Luleå :Luleå University of Technology,2018
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:ltu-68787
- ISBN:9789177901549
- ISBN:9789177901556
- https://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-68787URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Varying forms of title
- In vitro-löslighet och övermättningsegenskaperhos övermättat läkemedels-administrationssystem
Series
- Doctoral thesis / Luleå University of Technology 1 jan 1997 → …,1402-1544
Notes
- The development of new pharmaceutical products has been challenged by the growing number of poorly water-soluble drugs, which often lead to suboptimal bioavailability. Various approaches, such as the use of amor-phous solid dispersions and cocrystals, have been used to improve the solu-bility, and subsequent bioavailability, of these drug molecules. Supersaturat-ing drug delivery systems (SDDSs) have potential for achieving adequate oral drug bioavailability by increasing the drug solubility and creating a su-persaturated state in the gastrointestinal tract. However, there is a need for better understanding of the supersaturation behavior in SDDSs and of the factors affecting supersaturation. The main objective of this thesis was to improve understanding of the supersaturation solubility behavior in SDDSs with a particular focus on rapidly dissolving solid forms (amorphous forms/cocrystals).In the course of the work, a new formulation for ezetimibe using an amorphous solid dispersion was prepared, cocrystals of tadalafil were pre-pared, and oral films of silodosin were formulated for the first time. These new formulations were thoroughly characterized using a number of solid-state and pharmaceutical characterization techniques.The dissolution and supersaturation behavior of the prepared SDDSs were studied. The effects of various factors on the supersaturation and precipita-tion characteristics were investigated. These factors included the preparation method, the temperature of the dissolution medium, the type of dissolution biorelevant medium (gastric/intestinal) used, the permeability of the relevant gastrointestinal membranes, the addition of polymers, and the addition of surfactants. The amorphous solid dispersions, cocrystals and oral films that were prepared represent new drug formulations that provide significantly higher dissolution rates and supersaturated solubility than crystalline drug forms. Solid dispersions prepared by the melting method had better super-saturation properties than those prepared by spray drying. The precipitation kinetics of the solid dispersion were faster at 37 ̊C than at 25 ̊C in bio-relevant media. Implementation of an absorption tool during in vitro evalua-tion of supersaturation levels could improve the prediction accuracy of su-persaturation and precipitation. A better understanding of the effects of ex-cipients on the supersaturation and precipitation behavior of these types of formulation was obtained in this thesis. The improvement in supersaturation solubility obtained by adding polymers and surfactants was not proportional to the amounts of excipient used.This thesis has made notable contributions to the field of pharmaceutical science by advancing our understanding of the supersaturation solubility behavior of the newly prepared SDDSs.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Annan hälsovetenskap hsv//swe
- MEDICAL AND HEALTH SCIENCES Health Sciences Other Health Sciences hsv//eng
- Health Science
- Hälsovetenskap
Added entries (persons, corporate bodies, meetings, titles ...)
- Velaga, Sitaram P.Luleå tekniska universitet,Medicinsk vetenskap(Swepub:ltu)sitvel (thesis advisor)
- Klein, Sandra,ProfessorInstitute of Pharmacy, Biopharmaceutics and Pharmaceutical Technology, University of Greifswald, Greifswald, Tyskland (opponent)
- Luleå tekniska universitetMedicinsk vetenskap (creator_code:org_t)
Internet link
Find in a library
- In vitro-solubility and supersaturation behavior of supersaturating drug deliver... (Search the publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- AlHayali, Amani
- Velaga, Sitaram ...
- Klein, Sandra, P ...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Health Sciences
- and Other Health Sci ...
- Parts in the series
- Doctoral thesis ...
- By the university
- Luleå University of Technology
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
