Long-term Health Related Quality of Life in men with screening detected abdominal aortic aneurysm: A five-year follow-up study.

• Objective: To investigate how HRQoL and comorbidity differs in men with screening detected abdominal aortic aneurysm (AAA), sub-aneurysmal aorta (SAA) and controls screened with a normal aorta, measured after baseline screening and at five-year follow-up.Methods: Between 2006 and 2015, 19 738 65-year old men were invited and 16 689 participated in the AAA screening program in the county of Uppsala in Sweden. All 539 men diagnosed with an SAA or AAA were invited to participate in the study, of whom 324 accepted. HRQoL (RAND-36) and health questionnaires was distributed approximately two weeks after screening, and at 5-year follow-up. For each year a control group of approx. 50 men with normal aortic diameter at screening were included. Results: Compared with controls, AAA and SAA patients reported significantly lower scores in the dimensions Physical Function (Mean 90.6 vs 84.8 p=0.005 and 81.3 p=0.002), General Health (76.7 vs 71.0 p=0.005 and 67.5 p<0.001), and Vitality (78.2 vs 73.2 p=0.049 and 69.6 p=0.003) with a corresponding higher prevalence of co-morbidity at baseline. After 5 years of follow-up, SAA and AAA patients showed a further reduction in HRQoL scores in several dimensions. Despite a significantly higher comorbidity burden among AAA patients (vs SAA), the numerical difference in HRQoL between the two groups was not significant. Conclusion: AAA and SAA patients are burdened with a higher degree of comorbidity and an associated impaired HRQoL at baseline screening, with a further deterioration during long-term follow-up up to 5 years, with an associated deterioration in health.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kirurgi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Surgery (hsv//eng)

Nyckelord

health related quality of life

abdominal aortic aneurysm

sub-aneurysmal aorta

Screening

Meta-analysis

Patient experience

Quality of life

Systematic review

Medicinsk vetenskap

Medical Science

Publikations- och innehållstyp

vet (ämneskategori)

ovr (ämneskategori)