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Chapter Six - The r...
Chapter Six - The role of membrane vesiculation and encapsulation in cancer diagnosis and therapy
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- Drab, Mitja (författare)
- Laboratory of Physics, Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia.Laboratory of Clinical Biophysics, Chair of Orthopaedic Surgery, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
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- Mesarec, Luka (författare)
- Laboratory of Physics, Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia
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- Imani, Roghayeh (författare)
- Luleå tekniska universitet,Institutionen för teknikvetenskap och matematik
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- Jeran, Marko (författare)
- Laboratory of Physics, Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia. Laboratory of Clinical Biophysics, Faculty of Health Sciences, University of Ljubljana, Ljubljana, Slovenia
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- Junkar, Ita (författare)
- Department of Surface Engineering and Optoelectronics, “Jožef Stefan” Institute, Ljubljana, Slovenia
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- Kralj-Iglič, Veronika (författare)
- Laboratory of Clinical Biophysics, Faculty of Health Sciences, University of Ljubljana, Ljubljana, Slovenia. Institute of Biosciences and BioResources, National Research Council of Italy, Italy
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- Kralj, Samo (författare)
- Condensed Matter Physics Department, “Jožef Stefan” Institute, Ljubljana, Slovenia. Faculty of Natural Sciences and Mathematics, University of Maribor, Maribor, Slovenia
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- Iglič, Aleš (författare)
- Laboratory of Physics, Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia. Laboratory of Clinical Biophysics, Chair of Orthopaedic Surgery, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. Institute of Biosciences and BioResources, National Research Council of Italy, Italy
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Laboratory of Physics, Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, SloveniaLaboratory of Clinical Biophysics, Chair of Orthopaedic Surgery, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia Laboratory of Physics, Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia (creator_code:org_t)
- Elsevier, 2019
- 2019
- Engelska.
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Ingår i: Advances in Biomembranes and Lipid Self-Assembly. - : Elsevier. - 2451-9634. ; 29, s. 159-199
- Relaterad länk:
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https://zenodo.org/r...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- We summarize recent findings and advances in cancer diagnostics in relation to extracellular vesicles (EVs) and emerging therapeutic options of nanomaterials. We revise the common mechanism for EV inception, vesiculation, through a physical model of the liquid mosaic membrane with laterally mobile membrane rafts that determine local spontaneous curvature. If such in-plane orientational ordering is present, we show that spatial non-homogeneities may trigger energetically favourable membrane vesiculation. In addition, we revise a novel technique of cancer therapy using multifunctional titanium nanobeads (NBs) that form a fully biocompatible system used for optical imaging, magnetic resonance imaging and selective reactive oxygen species photo-generation. We study the encapsulation of these functional NBs theoretically with Monte Carlo (MC) simulations and find that the wrapping transition depends on the strength of mobile charges, giving insight into future functional optimization for maximum therapeutic benefit.
Ämnesord
- NATURVETENSKAP -- Fysik -- Annan fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Other Physics Topics (hsv//eng)
Nyckelord
- Cancer
- Extracellular vesicles
- Vesiculation
- Topological defects
- Mesoporous nanobeads
- Encapsulation
- Experimentell fysik
- Experimental Physics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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