Fabrication and characterization of novel bilayer scaffold from nanocellulose based aerogel for skin tissue engineering applications

Ghafari, RobabDepartment of Wood and Paper Sciences and Technology, Faculty of Natural Resources, University of Tehran, Karaj, Iran (författare)

Validerad;2019;Nivå 2;2019-06-28 (svasva)
The aim of this study was to fabricate a novel bilayer scaffold containing cellulose nanofiber/poly (vinyl) alcohol (CNF/PVA) to evaluate its potential use in skin tissue engineering. Here, the scaffolds were fabricated using a novel one-step freeze-drying technique with two different concentrations of the aforementioned polymers. FE-SEM analysis indicated that the fabricated scaffolds had interconnected pores with two defined pore size in each layer of the bilayer scaffolds that can recapitulate the two layers of the dermis and epidermis of the skin. Lower concentration of polymers causes higher porosity with larger pore size and increased water uptake and decreased mechanical strength. FTIR proved the presence of functional groups and strong hydrogen bonding between the molecules of CNF/PVA and the efficient crosslinking. The MTT assay showed that these nanofibrous scaffolds meet the requirement as a biocompatible material for skin repair. Here, for the first time, we fabricated bilayer scaffold using a novel one-step freeze-drying technique only by controlling the polymer concentration with spending less time and energy.

Jonoobi, MehdiDepartment of Wood and Paper Sciences and Technology, Faculty of Natural Resources, University of Tehran, Karaj, Iran (författare)
Mohammadi Amirabad, LeilaMarquette University, School of Dentistry, Milwaukee, WI, USA (författare)
Oksman, Kristiina,1959-Luleå tekniska universitet,Materialvetenskap(Swepub:ltu)krioks (författare)
Taheri, Ahmad RezaDepartment of Plastic Surgery, Imam Khomeini Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran (författare)
Department of Wood and Paper Sciences and Technology, Faculty of Natural Resources, University of Tehran, Karaj, IranMarquette University, School of Dentistry, Milwaukee, WI, USA (creator_code:org_t)

Ingår i:International Journal of Biological Macromolecules: Elsevier136, s. 796-8030141-81301879-0003

Av författaren/redakt...: Ghafari, Robab; Jonoobi, Mehdi; Mohammadi Amirab ...; Oksman, Kristiin ...; Taheri, Ahmad Re ...

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