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Bypassing mitochond...
Bypassing mitochondrial complex III using alternative oxidase inhibits acute pulmonary oxygen sensing
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- Sommer, Natascha (författare)
- Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany
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- Alebrahimdehkordi, Nasim (författare)
- Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany
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- Pak, Oleg (författare)
- Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany
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- Knoepp, Fenja (författare)
- Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany
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- Strielkov, Ievgen (författare)
- Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany
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- Scheibe, Susan (författare)
- Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany
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- Dufour, Eric (författare)
- Faculty of Medicine and Health Technology, Tampere University, FI-33014 Tampere, Finland
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- Andjelković, Ana (författare)
- Faculty of Medicine and Health Technology, Tampere University, FI-33014 Tampere, Finland
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- Sydykov, Akylbek (författare)
- Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany
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- Saraji, Alireza (författare)
- Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany
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- Petrovic, Aleksandar (författare)
- Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany
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- Quanz, Karin (författare)
- Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany
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- Hecker, Matthias (författare)
- Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany
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- Kumar, Manish (författare)
- Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany
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- Wahl, Joel (författare)
- Luleå tekniska universitet,Strömningslära och experimentell mekanik
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- Kraut, Simone (författare)
- Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany
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- Seeger, Werner (författare)
- Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany
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- Schermuly, Ralph T. (författare)
- Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany
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- Ghofrani, Hossein A. (författare)
- Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany. Department of Medicine, Imperial College London, Du Cane Road, Hammersmith Campus, London W12 0NN, UK
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- Ramser, Kerstin (författare)
- Luleå tekniska universitet,Strömningslära och experimentell mekanik
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- Braun, Thomas (författare)
- Department I, Cardiac Development and Remodelling, Max Planck Institute for Heart and Lung Research, D-61231 Bad Nauheim, Germany
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- Jacobs, Howard T. (författare)
- Faculty of Medicine and Health Technology, Tampere University, FI-33014 Tampere, Finland
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- Weissmann, Norbert (författare)
- Excellence Cluster Cardio-Pulmonary Institute (CPI), University of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, D-35392 Giessen, Germany
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- Szibor, Marten (författare)
- Faculty of Medicine and Health Technology, Tampere University, FI-33014 Tampere, Finland
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(creator_code:org_t)
- American Association for the Advancement of Science, 2020
- 2020
- Engelska.
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Ingår i: Science Advances. - : American Association for the Advancement of Science. - 2375-2548. ; 6:16
- Relaterad länk:
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https://advances.sci...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Mitochondria play an important role in sensing both acute and chronic hypoxia in the pulmonary vasculature, but their primary oxygen-sensing mechanism and contribution to stabilization of the hypoxia-inducible factor (HIF) remains elusive. Alteration of the mitochondrial electron flux and increased superoxide release from complex III has been proposed as an essential trigger for hypoxic pulmonary vasoconstriction (HPV). We used mice expressing a tunicate alternative oxidase, AOX, which maintains electron flux when respiratory complexes III and/or IV are inhibited. Respiratory restoration by AOX prevented acute HPV and hypoxic responses of pulmonary arterial smooth muscle cells (PASMC), acute hypoxia-induced redox changes of NADH and cytochrome c, and superoxide production. In contrast, AOX did not affect the development of chronic hypoxia-induced pulmonary hypertension and HIF-1α stabilization. These results indicate that distal inhibition of the mitochondrial electron transport chain in PASMC is an essential initial step for acute but not chronic oxygen sensing.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Maskinteknik -- Teknisk mekanik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Mechanical Engineering -- Applied Mechanics (hsv//eng)
Nyckelord
- Experimental Mechanics
- Experimentell mekanik
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Sommer, Natascha
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Alebrahimdehkord ...
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Pak, Oleg
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Knoepp, Fenja
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Strielkov, Ievge ...
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Scheibe, Susan
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Dufour, Eric
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Andjelković, Ana
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Sydykov, Akylbek
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Saraji, Alireza
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Petrovic, Aleksa ...
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Quanz, Karin
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Hecker, Matthias
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Kumar, Manish
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Wahl, Joel
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Kraut, Simone
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Seeger, Werner
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Schermuly, Ralph ...
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Ghofrani, Hossei ...
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Ramser, Kerstin
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Braun, Thomas
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Jacobs, Howard T ...
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Weissmann, Norbe ...
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Szibor, Marten
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