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Genetic Studies of ...
Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity
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- Yaghootkar, Hanieh (författare)
- Luleå tekniska universitet,Medicinsk vetenskap,Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, U.K.; Research Centre for Optimal Health, School of Life Sciences, University of Westminster, London, U.K.,Univ Exeter, Royal Devon & Exeter Hosp, Genet Complex Traits, Med Sch, Exeter, Devon, England.;Luleå Univ Technol, Div Med Sci, Dept Hlth Sci, Luleå, Sweden.;Univ Westminster, Sch Life Sci, Res Ctr Optimal Hlth, London, England.
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- Zhang, Yiying (författare)
- Division of Molecular Genetics, Department of PediatriQuantinuum Research LLC, San Diego, CAcs, Columbia University, New York, NY, U.S.,Columbia Univ, Dept Pediat, Div Mol Genet, New York, NY 10027 USA.
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- Spracklen, Cassandra N. (författare)
- Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, U.S.; Department of Biostatistics and Epidemiology, University of Massachusetts-Amherst, Amherst, MA, U.S.,Univ N Carolina, Dept Genet, Chapel Hill, NC 27515 USA.;Univ Massachusetts, Dept Biostat & Epidemiol, Amherst, MA 01003 USA.
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- Karaderi, Tugce (författare)
- Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.; Department of Biological Sciences, Faculty of Arts and Sciences, Eastern Mediterranean University, Famagusta, Cyprus; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; DTU Health Technology, Technical University of Denmark, Lyngby, Denmark,Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Eastern Mediterranean Univ, Fac Arts & Sci, Dept Biol Sci, Gazimagusa, Cyprus.;Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn, Ctr Prot Res, Copenhagen, Denmark.;Tech Univ Denmark, DTU Hlth Technol, Lyngby, Denmark.
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- Huang, Lam Opal (författare)
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn, Ctr Basic Metab Res, Copenhagen, Denmark.
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- Bradfield, Jonathan (författare)
- Center for Applied Genomics, Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, PA, U.S.; Quantinuum Research LLC, San Diego, CA, U.S.,Childrens Hosp Philadelphia, Div Human Genet, Ctr Appl Gen, Philadelphia, PA 19104 USA.;Quantinuum Res LLC, San Diego, CA USA.
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- Schurmann, Claudia (författare)
- The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, U.S.,Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.
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- Fine, Rebecca S. (författare)
- Department of Genetics, Harvard Medical School, Boston, MA, U.S.; Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Boston, MA, U.S.; Broad Institute of MIT and Harvard, Cambridge, MA, U.S.,Harvard Med Sch, Dept Genet, Boston, MA 02115 USA.;Boston Childrens Hosp, Div Endocrinol, Boston, MA USA.;Boston Childrens Hosp, Ctr Basic & Translat Obes Res, Boston, MA USA.;Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.
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- Preuss, Michael H. (författare)
- The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, U.S.,Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.,Childrens Hosp Philadelphia, Div Human Genet, Ctr Appl Gen, Philadelphia, PA 19104 USA.;Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA.,Center for Applied Genomics, Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, PA, U.S.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, U.S.
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- Kutalik, Zultan (författare)
- Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, U.K.; Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland,Univ Exeter, Royal Devon & Exeter Hosp, Genet Complex Traits, Med Sch, Exeter, Devon, England.;Univ Lausanne, Ctr Primary Care & Publ Hlth, Lausanne, Switzerland.;Swiss Inst Bioinformat, Lausanne, Switzerland.
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- Lind, Lars (författare)
- Uppsala universitet,Klinisk epidemiologi,Univ N Carolina, Dept Genet, Chapel Hill, NC 27515 USA.,Columbia Univ, Dept Pediat, Div Mol Genet, New York, NY 10027 USA.,Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.; MRC Epidemiology Unit, University of Cambridge, Cambridge, U.K.,Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, U.S.,Joseph J. Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, U.S.,Department of Medical Sciences, Uppsala University, Uppsala, Sweden,Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, U.S.,Division of Molecular Genetics, Department of Pediatrics, Columbia University, New York, NY, U.S.
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- Lu, Yingchang (författare)
- The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, U.S.; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, and Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN, U.S.,Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.;Vanderbilt Univ, Sch Med, Dept Med, Div Epidemiol,Vanderbilt Ingram Canc Ctr, Nashville, TN 37212 USA.;Vanderbilt Univ, Sch Med, Vanderbilt Epidemiol Ctr, Nashville, TN 37212 USA.
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- Metz, Sophia (författare)
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn, Ctr Basic Metab Res, Copenhagen, Denmark.
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- Willems, Sara M. (författare)
- MRC Epidemiology Unit, University of Cambridge, Cambridge, U.K.,Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.,Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England.;Guys & St Thomas Fdn Trust, NIHR Biomed Res Ctr, London, England.,Department of Twin Research and Genetic Epidemiology, Kings College London, London, U.K.; NIHR Biomedical Research Centre at Guy’s and St Thomas’ Foundation Trust, London, U.K.
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- Li-Gao, Ruifang (författare)
- Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands,Leiden Univ, Dept Clin Epidemiol, Med Ctr, Leiden, Netherlands.
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- Grarup, Niels (författare)
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn, Ctr Basic Metab Res, Copenhagen, Denmark.
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- Wang, Shuai (författare)
- Department of Biostatistics, Boston University School of Public Health, Boston, MA, U.S.,Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA.
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- Molnos, Sophie (författare)
- German Center for Diabetes Research, München-Neuherberg, Germany; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, München-Neuherberg, Germany,German Ctr Diabet Res, Munich, Germany.;Ctr Environm Hlth, Res Unit Mol Epidemiol, Helmholtz Zentrum Munchen Res, Inst Epidemiol, Munich, Germany.
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- Sandoval-Zárate, América A. (författare)
- Institute for Molecular Medicine Finland, Helsinki, Finland,Inst Mol Med Finland, Helsinki, Finland.
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- Nalls, Mike A. (författare)
- Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, U.S.; Data Tecnica International, Glen Echo, MD, U.S.,NIA, Lab Neurogenet, NIH, Bethesda, MD 20892 USA.;Data Tecn Int, Glen Echo, MD USA.
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- Lange, Leslie A. (författare)
- Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado-Denver, Denver, CO, U.S.,Univ Colorado, Dept Med, Div Biomed Informat & Personalized Med, Denver, CO USA.,Univ Wisconsin, Joseph J Zilber Sch Publ Hlth, Milwaukee, WI 53201 USA.
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- Haesser, Jeffrey (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, U.S.,Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
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- Guo, Xiuqing (författare)
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, U.S.,Harbor UCLA Med Ctr, Dept Pediat, Lundquist Inst Biomed Innovat, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA.
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- Lyytikäinen, Leo-Pekka (författare)
- Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland,Fimlab Labs, Dept Clin Chem, Tampere, Finland.;Tampere Univ, Fac Med & Hlth Technol, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Chem, Tampere, Finland.
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- Feitosa, Mary (författare)
- Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, U.S.,Washington Univ, Sch Med, Dept Genet, Div Stat Gen, St Louis, MO 63110 USA.
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- Sitlani, Colleen M. (författare)
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, U.S.,Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA.
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- Venturini, Cristina (författare)
- Department of Twin Research and Genetic Epidemiology, Kings College London, London, U.K.,Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England.
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- Mahajan, Anubha (författare)
- Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, U.K.,Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Radcliffe Dept Med, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.
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- Kacprowski, Tim (författare)
- Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany,Univ Med Greifswald, Interfac Inst Genet & Funct Genom, Dept Funct Genom, Greifswald, Germany.;DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany.
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- Wang, Carol A. (författare)
- Department of Biostatistics, Boston University School of Public Health, Boston, MA, U.S.,Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA.
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- Chasman, Daniel I. (författare)
- Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA, U.S.; Harvard Medical School, Boston, MA, U.S.,Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.
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- Amin, Najaf (författare)
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands,Erasmus MC, Univ Med Ctr Rotterdam, Dept Epidemiol, Rotterdam, Netherlands.
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- Broer, Linda (författare)
- Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands
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- Robertson, Neil (författare)
- Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.,Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Oxford, Radcliffe Dept Med, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.
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- Young, Kristin L. (författare)
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, U.S.,Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27515 USA.
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- Allison, Matthew (författare)
- Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, U.S.,Univ Calif San Diego, Dept Family Med & Publ Hlth, La Jolla, CA 92093 USA.
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- Auer, Paul L. (författare)
- Joseph J. Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, U.S.
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- Blüher, Matthias (författare)
- Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany,Univ Leipzig, Med Dept Endocrinol 3, Nephrol, Med Ctr,Rheumatol, Leipzig, Germany.
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- Borja, Judith B. (författare)
- Office of Population Studies Foundation, Inc., Cebu City, Philippines; Department of Nutrition and Dietetics, University of San Carlos, Cebu City, Philippines,Off Populat Studies Fdn Inc, Cebu, Philippines.;Univ San Carlos, Dept Nutr & Dietet, Cebu, Philippines.
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- Bork-Jensen, Jette (författare)
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn, Ctr Basic Metab Res, Copenhagen, Denmark.
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- Carrasquilla, Germán D. (författare)
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn, Ctr Basic Metab Res, Copenhagen, Denmark.
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- Christofidou, Paraskevi (författare)
- Department of Twin Research and Genetic Epidemiology, Kings College London, London, U.K.,Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England.
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- Demirkan, Ayse (författare)
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands,Erasmus MC, Univ Med Ctr Rotterdam, Dept Epidemiol, Rotterdam, Netherlands.
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- Doege, Claudia A. (författare)
- Department of Pathology and Cell Biology, Columbia University, New York, NY, U.S.,Columbia Univ, Dept Pathol & Cell Biol, New York, NY USA.
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- Garcia, Melissa E. (författare)
- Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, U.S.,NIA, Lab Epidemiol & Populat Sci, Bethesda, MD 20892 USA.
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- Graff, Mariaelisa (författare)
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, U.S.; Carolina Center for Genome Sciences, Chapel Hill, NC, U.S.,Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27515 USA.;Carolina Ctr Genome Sci, Chapel Hill, NC USA.
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- Guo, Kaiying (författare)
- Division of Molecular Genetics, Department of Pediatrics, Columbia University, New York, NY, U.S.,Columbia Univ, Dept Pediat, Div Mol Genet, New York, NY 10027 USA.
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- Hakonarson, Hakon (författare)
- Center for Applied Genomics, Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, PA, U.S.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, U.S.
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- Hong, Jaeyoung (författare)
- Department of Biostatistics, Boston University School of Public Health, Boston, MA, U.S.,Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA.
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- Chen, Yii-Der Ida (författare)
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, U.S.,Harbor UCLA Med Ctr, Dept Pediat, Lundquist Inst Biomed Innovat, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA.
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- Jackson, Rebecca (författare)
- Division of Endocrinology, Diabetes, and Metabolism, Ohio State University, Columbus, OH, U.S.,Ohio State Univ, Div Endocrinol Diabet & Metab, Columbus, OH 43210 USA.
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- Jakupović, Hermina (författare)
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn, Ctr Basic Metab Res, Copenhagen, Denmark.
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- Jousilahti, Pekka (författare)
- Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland,Finnish Inst Hlth & Welf, Dept Publ Hlth Solut, Helsinki, Finland.
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- Justice, Anne E. (författare)
- Center for Biomedical and Translational Informatics, Geisinger, Danville, PA, U.S.,Ctr Biomed & Translat Informat, Danville, PA USA.
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- Kähönen, Mika (författare)
- Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland; Department of Clinical Physiology, Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland,Tampere Univ Hosp, Dept Clin Physiol, Tampere, Finland.;Tampere Univ, Fac Med & Hlth Technol, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Physiol, Tampere, Finland.
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- Kizer, Jorge R. (författare)
- Cardiology Section, San Francisco Veterans Affairs Health Care System, University of California San Francisco, San Francisco, CA, U.S.; Departments of Medicine and Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, U.S.,Univ Calif San Francisco, San Francisco Vet Affairs Hlth Care Syst, Cardiol Sect, San Francisco, CA 94143 USA.;Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA.;Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.
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- Kriebel, Jennifer (författare)
- German Center for Diabetes Research, München-Neuherberg, Germany; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, München-Neuherberg, Germany,German Ctr Diabet Res, Munich, Germany.;Ctr Environm Hlth, Res Unit Mol Epidemiol, Helmholtz Zentrum Munchen Res, Inst Epidemiol, Munich, Germany.
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- LeDuc, Charles A. (författare)
- Division of Molecular Genetics, Department of Pediatrics, Columbia University, New York, NY, U.S.,Columbia Univ, Dept Pediat, Div Mol Genet, New York, NY 10027 USA.
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- Li, Jin (författare)
- Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Palo Alto, CA, U.S.,Stanford Univ, Dept Med, Div Cardiovasc Med, Palo Alto, CA 94304 USA.
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- Lind, Lars (författare)
- Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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- Luan, Jian'an (författare)
- MRC Epidemiology Unit, University of Cambridge, Cambridge, U.K.,Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.
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- Mackey, David A. (författare)
- Centre for Ophthalmology and Visual Science, Lions Eye Institute, The University of Western Australia, Perth, West Australia, Australia,Univ Western Australia, Lions Eye Inst, Ctr Ophthalmol & Visual Sci, Perth, WA, Australia.
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- Mangino, Massimo (författare)
- Department of Twin Research and Genetic Epidemiology, Kings College London, London, U.K.; NIHR Biomedical Research Centre at Guy’s and St Thomas’ Foundation Trust, London, U.K.,Univ Washington, Dept Epidemiol, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA.;Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA.;Univ Washington, Dept Hlth Serv, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA.;Kaiser Permanente Washington Hlth Res Inst, Seattle, WA USA.,Erasmus MC, Univ Med Ctr Rotterdam, Dept Epidemiol, Rotterdam, Netherlands.;Erasmus MC, Univ Med Ctr Rotterdam, Dept Internal Med, Rotterdam, Netherlands.,Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.,Univ Exeter, Royal Devon & Exeter Hosp, Genet Complex Traits, Med Sch, Exeter, Devon, England.,Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.;Univ Oxford, Big Data Inst, Nuffield Dept Med, Oxford, England.,Cardiovascular Health Research Unit, Departments of Epidemiology, Medicine, and Health Services, University of Washington, Seattle, WA, U.S.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, U.S.,Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands,Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA, U.S.; Harvard Medical School, Boston, MA, U.S.,Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, U.K.,Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.; Broad Institute of MIT and Harvard, Cambridge, MA, U.S.; Big Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
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- Männistö, Satu (författare)
- Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland,Finnish Inst Hlth & Welf, Dept Publ Hlth Solut, Helsinki, Finland.
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- Martin Carli, Jayne F. (författare)
- Division of Molecular Genetics, Department of Pediatrics, Columbia University, New York, NY, U.S.,Columbia Univ, Dept Pediat, Div Mol Genet, New York, NY 10027 USA.
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- Medina-Gomez, Carolina (författare)
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands,Erasmus MC, Univ Med Ctr Rotterdam, Dept Epidemiol, Rotterdam, Netherlands.;Erasmus MC, Univ Med Ctr Rotterdam, Dept Internal Med, Rotterdam, Netherlands.
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- Mook-Kanamori, Dennis (författare)
- Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands,Leiden Univ, Dept Clin Epidemiol, Med Ctr, Leiden, Netherlands.;Leiden Univ, Dept Publ Hlth & Primary Care, Med Ctr, Leiden, Netherlands.
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- Morris, Andrew P. (författare)
- Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.; Department of Biostatistics, University of Liverpool, Liverpool, U.K.; Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, U.K.,Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.;Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England.;Univ Manchester, Div Musculoskeletal & Dermatol Sci, Manchester, Lancs, England.
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- de Mutsert, Renée (författare)
- Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands,Leiden Univ, Dept Clin Epidemiol, Med Ctr, Leiden, Netherlands.
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- Nauck, Matthias (författare)
- DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany,DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany.;Univ Med Greifswald, Inst Clin Chem & Lab Med, Greifswald, Germany.
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- Prokic, Ivana (författare)
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands,Erasmus MC, Univ Med Ctr Rotterdam, Dept Epidemiol, Rotterdam, Netherlands.
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- Pennell, Craig E. (författare)
- Department of Biostatistics, Boston University School of Public Health, Boston, MA, U.S.,Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA.
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- Pradhan, Arund D. (författare)
- Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA, U.S.; Harvard Medical School, Boston, MA, U.S.,Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.
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- Psaty, Bruce M. (författare)
- Cardiovascular Health Research Unit, Departments of Epidemiology, Medicine, and Health Services, University of Washington, Seattle, WA, U.S.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, U.S.
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- Raitakari, Olli T. (författare)
- Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, Turku University Hospital, Turku, Finland,Univ Turku, Ctr Populat Hlth Res, Turku, Finland.;Turku Univ Hosp, Turku, Finland.;Turku Univ Hosp, Dept Clin Physiol & Nucl Med, Turku, Finland.;Turku Univ Hosp, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland.
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- Scott, Robert A. (författare)
- MRC Epidemiology Unit, University of Cambridge, Cambridge, U.K.,Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.
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- Skaaby, Tea (författare)
- Center for Clinical Research and Disease Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark,Bispebjerg & Frederiksberg Hosp, Ctr Clin Res & Dis Prevent, Copenhagen, Denmark.
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- Strauch, Konstantin (författare)
- Institute of Genetic Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany; Chair of Genetic Epidemiology, Insitute of Medical Information Processing, Biometry, and Epidemiology (IBE), Faculty of Medicine, Ludwig Maximilian University Munich, München, Germany,German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Genet Epidemiol, Neuherberg, Germany.;Ludwig Maximilian Univ Munich, Fac Med, Inst Med Informat Proc Biometry & Epidemiol IBE, Chair Genet Epidemiol, Munich, Germany.
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- Taylor, Kent D. (författare)
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA,Harbor UCLA Med Ctr, Dept Pediat, Lundquist Inst Biomed Innovat, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA.
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- Teumer, Alexander (författare)
- DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany,DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany.;Univ Med Greifswald, Inst Community Med, Greifswald, Germany.
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- Uitterlinden, Andre G. (författare)
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands,Erasmus MC, Univ Med Ctr Rotterdam, Dept Epidemiol, Rotterdam, Netherlands.;Erasmus MC, Univ Med Ctr Rotterdam, Dept Internal Med, Rotterdam, Netherlands.
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- Wu, Ying (författare)
- Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, U.S.,Univ N Carolina, Dept Genet, Chapel Hill, NC 27515 USA.
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- Yao, Jie (författare)
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, U.S.,Harbor UCLA Med Ctr, Dept Pediat, Lundquist Inst Biomed Innovat, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA.
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- Walker, Mark (författare)
- Institute of Cellular Medicine (Diabetes), Newcastle University, Newcastle upon Tyne, U.K.,Newcastle Univ, Inst Cellular Med Diabet, Newcastle Upon Tyne, Tyne & Wear, England.
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- North, Kari E. (författare)
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, U.S.,Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27515 USA.
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- Kovacs, Peter (författare)
- Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany,Univ Leipzig, Med Dept Endocrinol 3, Nephrol, Med Ctr,Rheumatol, Leipzig, Germany.
-
- Ikram, M. Arfan (författare)
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands
-
- van Duijn, Cornelia M. (författare)
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands
-
- Ridker, Paul M. (författare)
- Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA, U.S.; Harvard Medical School, Boston, MA, U.S.
-
- Lye, Stephen (författare)
- Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada,Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada.
-
- Homuth, Georg (författare)
- Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany,Univ Med Greifswald, Interfac Inst Genet & Funct Genom, Dept Funct Genom, Greifswald, Germany.
-
- Ingelsson, Erik (författare)
- Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Palo Alto, CA, U.S.; Stanford Cardiovascular Institute, Stanford University School of Medicine, Palo Alto, CA, U.S.; Stanford Diabetes Research Center, Stanford University, Stanford, CA, U.S.; Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden,Stanford Univ, Dept Med, Div Cardiovasc Med, Palo Alto, CA 94304 USA.;Stanford Univ, Sch Med, Stanford Cardiovasc Inst, Palo Alto, CA 94304 USA.;Stanford Univ, Stanford Diabet Res Ctr, Stanford, CA 94305 USA.;Uppsala Univ, Dept Med Sci, Mol Epidemiol & Sci Life Lab, Uppsala, Sweden.
-
- Spector, Tim D. (författare)
- Department of Twin Research and Genetic Epidemiology, Kings College London, London, U.K.,Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England.
-
- McKnight, Barbara (författare)
- Department of Biostatistics, University of Washington, Seattle, WA, U.S.,Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
-
- Province, Michael A. (författare)
- Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, U.S.,Washington Univ, Sch Med, Dept Genet, Div Stat Gen, St Louis, MO 63110 USA.
-
- Lehtimäki, Terho (författare)
- Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland,Fimlab Labs, Dept Clin Chem, Tampere, Finland.;Tampere Univ, Fac Med & Hlth Technol, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Chem, Tampere, Finland.
-
- Adair, Linda S. (författare)
- Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, U.S.,Univ N Carolina, Carolina Populat Ctr, Chapel Hill, NC 27515 USA.
-
- Rotter, Jerome I. (författare)
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, U.S.,Harbor UCLA Med Ctr, Dept Pediat, Lundquist Inst Biomed Innovat, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA.
-
- Reiner, Alexander P. (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, U.S.,Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
-
- Wilson, James G. (författare)
- Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, U.S.,Univ Mississippi, Med Ctr, Dept Phys & Biophys, Jackson, MS 39216 USA.
-
- Harris, Tamara B. (författare)
- Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, MD, U.S.,NIA, Lab Epidemiol & Populat Sci, NIH, Bethesda, MD 20892 USA.
-
- Ripatti, Samuli (författare)
- Broad Institute of MIT and Harvard, Cambridge, MA, U.S.; Institute for Molecular Medicine Finland, Helsinki, Finland; Public Health, University of Helsinki, Helsinki, Finland,Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.;Inst Mol Med Finland, Helsinki, Finland.;Univ Helsinki, Publ Hlth, Helsinki, Finland.
-
- Grallert, Harald (författare)
- German Center for Diabetes Research, München-Neuherberg, Germany; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, München-Neuherberg, Germany,German Ctr Diabet Res, Munich, Germany.;Ctr Environm Hlth, Res Unit Mol Epidemiol, Helmholtz Zentrum Munchen Res, Inst Epidemiol, Munich, Germany.
-
- Meigs, James B. (författare)
- Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, U.S.; Department of Medicine, Harvard Medical School, Boston, MA, U.S.; Program in Population and Medical Genetics, Broad Institute of MIT and Harvard, Cambridge, MA,Massachusetts Gen Hosp, Div Gen Internal Med, Boston, MA 02114 USA.;Harvard Med Sch, Dept Med, Boston, MA 02115 USA.;Broad Inst MIT & Harvard, Program Populat & Med Genet, Cambridge, MA 02142 USA.
-
- Salomaa, Veikko (författare)
- Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland,Finnish Inst Hlth & Welf, Dept Publ Hlth Solut, Helsinki, Finland.
-
- Hansen, Torben (författare)
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn, Ctr Basic Metab Res, Copenhagen, Denmark.
-
- van Dijk, Ko Willems (författare)
- Division of Endocrinology, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands; Einthoven Laboratory for Experimental Vascular Medicine, Leiden, the Netherlands; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands,Leiden Univ, Med Ctr, Dept Internal Med, Div Endocrinol, Leiden, Netherlands.;Einthoven Lab Expt Vasc Med, Leiden, Netherlands.;Leiden Univ, Dept Human Genet, Med Ctr, Leiden, Netherlands.
-
- Wareham, Nicholas J. (författare)
- MRC Epidemiology Unit, University of Cambridge, Cambridge, U.K.,Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.
-
- Grant, Struan F.A. (författare)
- Center for Applied Genomics, Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, PA, U.S.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, U.S.; Center for Spatial and Functional Genomics, Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, PA, U.S.; Division of Endocrinology and Diabetes, The Children’s Hospital of Philadelphia, Philadelphia, PA, U.S.; Institute of Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, U.S.,Childrens Hosp Philadelphia, Div Human Genet, Ctr Appl Gen, Philadelphia, PA 19104 USA.;Univ Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA.;Childrens Hosp Philadelphia, Div Human Genet, Ctr Spatial & Funct Genom, Philadelphia, PA 19104 USA.;Childrens Hosp Philadelphia, Div Endocrinol & Diabet, Philadelphia, PA 19104 USA.;Univ Penn, Inst Diabet Obes & Metab, Perelman Sch Med, Philadelphia, PA 19104 USA.
-
- Langenberg, Claudia (författare)
- MRC Epidemiology Unit, University of Cambridge, Cambridge, U.K.,Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.
-
- Frayling, Timothy M. (författare)
- Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, U.K.
-
- Lindgren, Cecilia M. (författare)
- Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.; Broad Institute of MIT and Harvard, Cambridge, MA, U.S.; Big Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
-
- Mohlke, Karen L. (författare)
- Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, U.S.
-
- Leibel, Rudolph L. (författare)
- Division of Molecular Genetics, Department of Pediatrics, Columbia University, New York, NY, U.S.
-
- Loos, Ruth J.F. (författare)
- The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, U.S; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, U.S.,Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA.
-
- Kilpeläinen, Tuomas O. (författare)
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, U.S.,Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn, Ctr Basic Metab Res, Copenhagen, Denmark.;Icahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlth, New York, NY 10029 USA.
-
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-
(creator_code:org_t)
- 2020-09-11
- 2020
- Engelska.
-
Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 69:12, s. 2806-2818
- Relaterad länk:
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https://doi.org/10.2...
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-
https://diabetes.dia...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Leptin influences food intake by informing the brain about the status of body fat stores. Rare LEP mutations associated with congenital leptin deficiency cause severe early-onset obesity that can be mitigated by administering leptin. However, the role of genetic regulation of leptin in polygenic obesity remains poorly understood. We performed an exome-based analysis in up to 57,232 individuals of diverse ancestries to identify genetic variants that influence adiposity-adjusted leptin concentrations. We identify five novel variants, including four missense variants, in LEP, ZNF800, KLHL31, and ACTL9, and one intergenic variant near KLF14. The missense variant Val94Met (rs17151919) in LEP was common in individuals of African ancestry only, and its association with lower leptin concentrations was specific to this ancestry (P = 2 × 10-16, n = 3,901). Using in vitro analyses, we show that the Met94 allele decreases leptin secretion. We also show that the Met94 allele is associated with higher BMI in young African-ancestry children but not in adults, suggesting that leptin regulates early adiposity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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