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  • Karlsson Sundbaum, JohannaUppsala universitet,Luleå tekniska universitet,Hälsa, medicin och rehabilitering,Department of Medical Sciences, Rheumatology, Uppsala University, SE-751 85, Uppsala, Sweden,Reumatologi,Department of Health Sciences, Luleå University of Technology, SE-971 87, Luleå, Sweden (author)

Genome-wide association study of liver enzyme elevation in rheumatoid arthritis patients starting methotrexate

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • Future Medicine Ltd,2021
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:ltu-87167
  • https://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-87167URI
  • https://doi.org/10.2217/pgs-2021-0064DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-462628URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Validerad;2021;Nivå 2;2021-10-20 (alebob);Forskningsfinansiär: Agnes and Mac Rudberg’s, Brunnberg’s, Selander’s and Thuréus’ Foundations at Uppsala University; Clinical Research Support (Avtal om Läkarutbildning och Forskning, ALF) at Uppsala University
  • Aim: To identify novel genetic variants predisposing to elevation of Alanine aminotransferase (ALT) in rheumatoid arthritis (RA) patients after initiation of methotrexate (MTX) treatment. Patients & methods: We performed genome-wide association studies in 198 RA patients starting MTX. Outcomes were maximum level of ALT and ALT >1.5-times the upper level of normal within the first 6 months of treatment. Results: RAVER2 (rs72675408) was significantly associated with maximum level of ALT (p = 4.36 × 10-8). This variant is in linkage disequilibrium with rs72675451, which is associated with differential expression of JAK1 and RAVER2. Conclusion: We found an association between ALT elevation and genetic variants that may regulate the expression of JAK1 and RAVER2. JAK1 encodes a janus kinase involved in the pathogenesis of RA.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Baecklund, Eva,1956-Uppsala universitet,Reumatologi(Swepub:uu)evaba786 (author)
  • Eriksson, Niclas,1978-Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab(Swepub:uu)nieri103 (author)
  • Kohnke, HugoUppsala universitet,Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab(Swepub:uu)hukoh103 (author)
  • Wallenberg, MatildaUppsala universitet,Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab,Svensk Dos AB, Box 2, SE-751 03, Uppsala, Sweden (author)
  • Cavalli, MarcoUppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab(Swepub:uu)marca978 (author)
  • Wadelius, Claes,1955-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik,Wadelius(Swepub:uu)claeswad (author)
  • Wadelius, MiaUppsala universitet,Science for Life Laboratory, SciLifeLab,Klinisk farmakogenomik och osteoporos(Swepub:uu)miawadel (author)
  • Hallberg, Pär,1974-Uppsala universitet,Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab(Swepub:uu)pahal677 (author)
  • Luleå tekniska universitetHälsa, medicin och rehabilitering (creator_code:org_t)

Related titles

  • In:Pharmacogenomics (London): Future Medicine Ltd22:15, s. 973-9821462-24161744-8042

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