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Angiotensin-Convert...
Angiotensin-Converting Enzyme 2 (SARS-CoV-2 receptor) expression in human skeletal muscle
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- Perez-Valera, Mario (författare)
- Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017 Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe "Físico" s/n, 35017 Las Palmas de Gran Canaria, Spain
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- Martinez-Canton, Miriam (författare)
- Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017 Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe "Físico" s/n, 35017 Las Palmas de Gran Canaria, Spain
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- Gallego-Selles, Angel (författare)
- Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017 Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe "Físico" s/n, 35017 Las Palmas de Gran Canaria, Spain
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- Galván-Alvarez, Victor (författare)
- Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017 Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe "Físico" s/n, 35017 Las Palmas de Gran Canaria, Spain
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- Gelabert-Rebato, Miriam (författare)
- Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017 Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe "Físico" s/n, 35017 Las Palmas de Gran Canaria, Spain
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- Morales-Alamo, David (författare)
- Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017 Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe "Físico" s/n, 35017 Las Palmas de Gran Canaria, Spain
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- Santana, Alfredo (författare)
- Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe "Físico" s/n, 35017 Las Palmas de Gran Canaria, Spain; Complejo Hospitalario Universitario Insular-Materno Infantil de Las Palmas de Gran Canaria, Clinical Genetics Unit, 35016 Las Palmas de Gran Canaria, Spain
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- Martin-Rodriguez, Saul (författare)
- Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017 Spain
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- Ponce-Gonzales, Jesus Gustavo (författare)
- Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017 Spain
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- Larsen, Steen (författare)
- Center of Healthy Ageing, Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark; Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland
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- Losa-Reyna, Jose (författare)
- Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017 Spain
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- Perez-Suarez, Ismael (författare)
- Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017 Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe "Físico" s/n, 35017 Las Palmas de Gran Canaria, Spain
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- Dorado, Cecilia (författare)
- Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017 Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe "Físico" s/n, 35017 Las Palmas de Gran Canaria, Spain
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- Curtelin, David (författare)
- Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe "Físico" s/n, 35017 Las Palmas de Gran Canaria, Spain
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- Gonzales-Henriquez, Juan Jose (författare)
- Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017 Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe "Físico" s/n, 35017 Las Palmas de Gran Canaria, Spain; Department of Mathematics, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017 Spain
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- Boushel, Robert (författare)
- School of Kinesiology, Faculty of Education, The University of British Columbia, Vancouver, BC, Canada
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- Hallen, Jostein (författare)
- Department of Physical Performance, The Norwegian School of Sport Sciences, Postboks, 4014 Ulleval Stadion, 0806 Oslo, Norway
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- de Pablos Velasco, Pedro (författare)
- Department of Endocrinology and Nutrition, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, Spain
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- Freixinet Guilart, Jorge (författare)
- Department of Thoracic Surgery, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain
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- Holmberg, Hans-Christer, 1958- (författare)
- Luleå tekniska universitet,Hälsa, medicin och rehabilitering,Department of Physiology and Pharmacology, Biomedicum C5, Karolinska Institute, Stockholm, Sweden
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- Helge, Jorn W (författare)
- Center of Healthy Ageing, Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark
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- Martin-Rincon, Marcos (författare)
- Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017 Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe "Físico" s/n, 35017 Las Palmas de Gran Canaria, Spain
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- Calbet, Jose A.L. (författare)
- Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017 Spain; Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe "Físico" s/n, 35017 Las Palmas de Gran Canaria, Spain; School of Kinesiology, Faculty of Education, The University of British Columbia, Vancouver, BC, Canada; Department of Physical Performance, The Norwegian School of Sport Sciences, Postboks, 4014 Ulleval Stadion, 0806 Oslo, Norway
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(creator_code:org_t)
- 2021-10-04
- 2021
- Engelska.
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Ingår i: Scandinavian Journal of Medicine and Science in Sports. - : John Wiley & Sons. - 0905-7188 .- 1600-0838. ; 31:12, s. 2249-2258
- Relaterad länk:
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https://doi.org/10.1...
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The study aimed to determine the levels of skeletal muscle Angiotensin-Converting Enzyme 2 (ACE2, the SARS-CoV-2 receptor) protein expression in men and women and assess whether ACE2 expression in skeletal muscle is associated with cardiorespiratory fitness and adiposity. The level of ACE2 in vastus lateralis muscle biopsies collected in previous studies from 170 men (age:19-65 yrs, weight:56-137 kg, BMI:23-44) and 69 women (age:18-55 yrs, weight:41-126 kg, BMI:22-39) was analysed in duplicate by western blot. VO2max was determined by ergospirometry and body composition by DXA. ACE2 protein expression was 1.8-fold higher in women than men (p=0.001, n=239). This sex difference disappeared after accounting for the percentage of body fat (fat %), VO2max per kg of legs lean mass (VO2max-LLM) and age (p=0.47). Multiple regression analysis showed that the fat % (β=0.47) is the main predictor of the variability in ACE2 protein expression in skeletal muscle, explaining 5.2 % of the variance. VO2max-LLM had also predictive value (β=0.09). There was a significant fat % by VO2max-LLM interaction, such that for subjects with low fat %, VO2max-LLM was positively associated with ACE2 expression while as fat % increased the slope of the positive association between VO2max-LLM and ACE2 was reduced. In conclusion, women express higher amounts of ACE2 in their skeletal muscles than men. This sexual dimorphism is mainly explained by sex differences in fat % and cardiorespiratory fitness. The percentage of body fat is the main predictor of the variability in ACE2 protein expression in human skeletal muscle.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)
Nyckelord
- Physiotherapy
- Fysioterapi
- Centre - Swedish Sports Technology and Performance Research Centre (SPORTC)
- Centrumbildning - Swedish Sports Technology and Performance Research Centre (SPORTC)
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Perez-Valera, Ma ...
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Martinez-Canton, ...
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Gallego-Selles, ...
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Galván-Alvarez, ...
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Gelabert-Rebato, ...
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Morales-Alamo, D ...
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Santana, Alfredo
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Martin-Rodriguez ...
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Ponce-Gonzales, ...
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Larsen, Steen
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Losa-Reyna, Jose
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Perez-Suarez, Is ...
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Dorado, Cecilia
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Curtelin, David
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Gonzales-Henriqu ...
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Boushel, Robert
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Hallen, Jostein
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de Pablos Velasc ...
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Freixinet Guilar ...
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Holmberg, Hans-C ...
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Helge, Jorn W
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Martin-Rincon, M ...
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Calbet, Jose A.L ...
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Luleå tekniska universitet
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Karolinska Institutet