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- Prajapati, PreetiDepartment of Physics, University of Lucknow, Lucknow, India (författare)
Molecular Structural, Hydrogen Bonding Interactions, and Chemical Reactivity Studies of Ezetimibe-L-Proline Cocrystal Using Spectroscopic and Quantum Chemical Approach
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
- 2022-02-15
- Frontiers Media S.A.2022
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:ltu-89748
- https://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-89748URI
- https://doi.org/10.3389/fchem.2022.848014DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-203720URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
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Anmärkningar
- Validerad;2022;Nivå 2;2022-03-18 (joosat);Funder: Centre of Excellence, Govt. of Uttar Pradesh (360/70-4-2019-1035/2018); DST-SERB project (CRG/2019/006671)
- Ezetimibe (EZT) being an anticholesterol drug is frequently used for the reduction of elevated blood cholesterol levels. With the purpose of improving the physicochemical properties of EZT, in the present study, cocrystals of ezetimibe with L-proline have been studied. Theoretical geometry optimization of EZT-L-proline cocrystal, energies, and structure–activity relationship was carried out at the DFT level of theory using B3LYP functional complemented by 6-311++G(d,p) basis set. To better understand the role of hydrogen bonding, two different models (EZT + L-proline and EZT + 2L-proline) of EZT-L-proline cocrystal were studied. Spectral techniques (FTIR and FT-Raman) combined with quantum chemical methodologies were successfully implemented for the detailed vibrational assignment of fundamental modes. It is a zwitterionic cocrystal hydrogen bonded with the OH group of EZT and the COO− group of L-proline. The existence and strength of hydrogen bonds were examined by a natural bond orbital analysis (NBO) supported by the quantum theory of atoms in molecule (QTAIM). Chemical reactivity was reflected by the HOMO–LUMO analysis. A smaller energy gap in the cocrystal in comparison to API shows that a cocrystal is softer and chemically more reactive. MEPS and Fukui functions revealed the reactive sites of cocrystals. The calculated binding energy of the cocrystal from counterpoise method was −11.44 kcal/mol (EZT + L-proline) and −26.19 kcal/mol (EZT + 2L-proline). The comparative study between EZT-L-proline and EZT suggest that cocrystals can be better used as an alternative to comprehend the effect of hydrogen bonding in biomolecules and enhance the pharmacological properties of active pharmaceutical ingredients (APIs).
Ämnesord och genrebeteckningar
- NATURVETENSKAP Kemi Fysikalisk kemi hsv//swe
- NATURAL SCIENCES Chemical Sciences Physical Chemistry hsv//eng
- NATURVETENSKAP Kemi Teoretisk kemi hsv//swe
- NATURAL SCIENCES Chemical Sciences Theoretical Chemistry hsv//eng
- NATURVETENSKAP Kemi hsv//swe
- NATURAL SCIENCES Chemical Sciences hsv//eng
- hydrogen bonds
- ezetimibe-L-proline
- quantum chemical calculations
- vibrational spectroscopy
- pharmaceutical cocrystal
- density functional theory calculations
- Chemistry of Interfaces
- Gränsytors kemi
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Pandey, JayaDepartment of Physics, University of Lucknow, Lucknow, India (författare)
- Tandon, PoonamDepartment of Physics, University of Lucknow, Lucknow, India (författare)
- Sinha, KirtiDepartment of Physics, University of Lucknow, Lucknow, India (författare)
- Shimpi, Manishkumar R.Stockholms universitet,Luleå tekniska universitet,Kemiteknik,Department of Materials and Environmental Chemistry, Stockholm University, Stockholm, Sweden,Institutionen för material- och miljökemi (MMK),Luleå University of Technology, Sweden(Swepub:su)mash2978 (författare)
- Department of Physics, University of Lucknow, Lucknow, IndiaKemiteknik (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Frontiers in Chemistry: Frontiers Media S.A.102296-2646
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