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A Subdural Bioelect...
A Subdural Bioelectronic Implant to Record Electrical Activity from the Spinal Cord in Freely Moving Rats
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- Harland, Bruce (författare)
- School of Pharmacy, The University of Auckland, Auckland, 1023 New Zealand
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- Aqrawe, Zaid (författare)
- School of Pharmacy, The University of Auckland, Auckland, 1023 New Zealand
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- Vomero, Maria (författare)
- Department of Microsystems Engineering (IMTEK), BrainLinks‐BrainTools Center, University of Freiburg, Freiburg, 79110 Germany
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- Boehler, Christian (författare)
- Department of Microsystems Engineering (IMTEK), BrainLinks‐BrainTools Center, University of Freiburg, Freiburg, 79110 Germany
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- Cheah, Ernest (författare)
- School of Pharmacy, The University of Auckland, Auckland, 1023 New Zealand
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- Raos, Brad (författare)
- School of Pharmacy, The University of Auckland, Auckland, 1023 New Zealand
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- Asplund, Maria (författare)
- Luleå tekniska universitet,Omvårdnad och medicinsk teknik,Department of Microsystems Engineering (IMTEK), BrainLinks‐BrainTools Center, University of Freiburg, Freiburg, 79110 Germany; Freiburg Institute for Advanced Studies (FRIAS), University of Freiburg, Freiburg, 79110 Germany
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- O'Carroll, Simon J. (författare)
- Department of Anatomy & Medical Imaging, School of Medical Sciences, The University of Auckland, Auckland, 1023 New Zealand
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- Svirskis, Darren (författare)
- School of Pharmacy, The University of Auckland, Auckland, 1023 New Zealand
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(creator_code:org_t)
- 2022-05-02
- 2022
- Engelska.
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Ingår i: Advanced Science. - : John Wiley & Sons. - 2198-3844. ; 9:20
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Bioelectronic devices have found use at the interface with neural tissue to investigate and treat nervous system disorders. Here, the development and characterization of a very thin flexible bioelectronic implant inserted along the thoracic spinal cord in rats directly in contact with and conformable to the dorsal surface of the spinal cord are presented. There is no negative impact on hind-limb functionality nor any change in the volume or shape of the spinal cord. The bioelectronic implant is maintained in rats for a period of 12 weeks. The first subdural recordings of spinal cord activity in freely moving animals are presented; rats are plugged in via a recording cable and allowed to freely behave and move around on a raised platform. Recordings contained multiple distinct voltage waveforms spatially localize to individual electrodes. This device has great potential to monitor electrical signaling in the spinal cord after an injury and in the future, this implant will facilitate the identification of biomarkers in spinal cord injury and recovery, while enabling the delivery of localized electroceutical and chemical treatments.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- bioelectronic implant
- electroceutical
- polyimide
- spinal cord implant
- spinal cord injury
- spinal recording
- Medical Engineering
- Medicinsk teknik
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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