SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Ji Hanlee)
 

Sökning: WFRF:(Ji Hanlee) > ALTEN: A High‐Fidel...

ALTEN: A High‐Fidelity Primary Tissue‐Engineering Platform to Assess Cellular Responses Ex Vivo

Law, Andrew M. K. (författare)
The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, 2010 Australia
Chen, Jiamin (författare)
Division of Oncology, Department of Medicine, Stanford University, California, 94305 USA
Colino‐Sanguino, Yolanda (författare)
Cancer Epigenetic Biology and Therapeutics Laboratory, Children's Cancer Institute, Randwick, NSW, 2052 Australia; School of Women's and Children's Health, Faculty of Medicine, University of New South Wales Sydney, NSW, 2052 Australia
visa fler...
de la Fuente, Laura Rodriguez (författare)
The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, 2010 Australia; Cancer Epigenetic Biology and Therapeutics Laboratory, Children's Cancer Institute, Randwick, NSW, 2052 Australia
Fang, Guocheng (författare)
Institute for Biomedical Materials and Devices (IBMD), Faculty of Science, The University of Technology Sydney, Ultimo, NSW, 2007 Australia
Grimes, Susan M. (författare)
Division of Oncology, Department of Medicine, Stanford University, California, 94305 USA
Lu, Hongxu (författare)
Institute for Biomedical Materials and Devices (IBMD), Faculty of Science, The University of Technology Sydney, Ultimo, NSW, 2007 Australia
Huang, Robert J. (författare)
Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University, California, 94305 USA
Boyle, Sarah T. (författare)
Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, SA, 5000 Australia
Venhuizen, Jeron (författare)
The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, 2010 Australia
Castillo, Lesley (författare)
The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, 2010 Australia
Tavakoli, Javad (författare)
School of Biomedical Engineering, Faculty of Engineering and Information Technology, University of Technology Sydney, NSW, 2007 Australia
Skhinas, Joanna N. (författare)
The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, 2010 Australia
Millar, Ewan K. A. (författare)
Department of Anatomical Pathology, NSW Health Pathology, St George Hospital, Kogarah, NSW, 2217 Australia; St George & Sutherland Clinical School, UNSW Sydney, NSW, 2217 Australia
Beretov, Julia (författare)
Department of Anatomical Pathology, NSW Health Pathology, St George Hospital, Kogarah, NSW, 2217 Australia; St George & Sutherland Clinical School, UNSW Sydney, NSW, 2217 Australia
Rossello, Fernando J. (författare)
Centre for Cancer Research, University of Melbourne, Parkville, VIC, 3010 Australia
Tipper, Joanne L. (författare)
Luleå tekniska universitet,Maskinelement,School of Biomedical Engineering, Faculty of Engineering and Information Technology, University of Technology Sydney, NSW, 2007 Australia; School of Mechanical Engineering, University of Leeds, LS2 9JT, UK
Ormandy, Christopher J. (författare)
The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, 2010 Australia; St. Vincent's Clinical School, Faculty of Medicine, University of New South Wales Sydney, NSW, 2010 Australia
Samuel, Michael S. (författare)
Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, SA, 5000 Australia; Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, 5000 Australia
Cox, Thomas R. (författare)
The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, 2010 Australia; St. Vincent's Clinical School, Faculty of Medicine, University of New South Wales Sydney, NSW, 2010 Australia
Martelotto, Luciano (författare)
Single Cell Core, Systems Biology, Harvard Medical School, Harvard University, Massachusetts, 02115 USA
Jin, Dayong (författare)
Institute for Biomedical Materials and Devices (IBMD), Faculty of Science, The University of Technology Sydney, Ultimo, NSW, 2007 Australia
Valdes‐Mora, Fatima (författare)
Cancer Epigenetic Biology and Therapeutics Laboratory, Children's Cancer Institute, Randwick, NSW, 2052 Australia; School of Women's and Children's Health, Faculty of Medicine, University of New South Wales Sydney, NSW, 2052 Australia
Ji, Hanlee P. (författare)
Division of Oncology, Department of Medicine, Stanford University, California, 94305 USA
Gallego‐Ortega, David (författare)
The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, 2010 Australia; Institute for Biomedical Materials and Devices (IBMD), Faculty of Science, The University of Technology Sydney, Ultimo, NSW, 2007 Australia; School of Biomedical Engineering, Faculty of Engineering and Information Technology, University of Technology Sydney, NSW, 2007 Australia; St. Vincent's Clinical School, Faculty of Medicine, University of New South Wales Sydney, NSW, 2010 Australia
visa färre...
 (creator_code:org_t)
2022-05-25
2022
Engelska.
Ingår i: Advanced Science. - : John Wiley & Sons. - 2198-3844. ; 9:21
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • To fully investigate cellular responses to stimuli and perturbations within tissues, it is essential to replicate the complex molecular interactions within the local microenvironment of cellular niches. Here, the authors introduce Alginate-based tissue engineering (ALTEN), a biomimetic tissue platform that allows ex vivo analysis of explanted tissue biopsies. This method preserves the original characteristics of the source tissue's cellular milieu, allowing multiple and diverse cell types to be maintained over an extended period of time. As a result, ALTEN enables rapid and faithful characterization of perturbations across specific cell types within a tissue. Importantly, using single-cell genomics, this approach provides integrated cellular responses at the resolution of individual cells. ALTEN is a powerful tool for the analysis of cellular responses upon exposure to cytotoxic agents and immunomodulators. Additionally, ALTEN's scalability using automated microfluidic devices for tissue encapsulation and subsequent transport, to enable centralized high-throughput analysis of samples gathered by large-scale multicenter studies, is shown.

Ämnesord

NATURVETENSKAP  -- Biologi -- Biofysik (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Biophysics (hsv//eng)
NATURVETENSKAP  -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)

Nyckelord

alginate
ex vivo drug screening
single-cell RNAseq
three dimensionalculture
tissue microenvironment
whole-tissue organoids
Machine Elements
Maskinelement

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy