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Genome-wide associa...
Genome-wide association study of liver enzyme elevation in an extended cohort of rheumatoid arthritis patients starting low-dose methotrexate
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- Cavalli, Marco (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Genomik och neurobiologi,Klinisk farmakogenomik och osteoporos
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- Eriksson, Niclas, 1978- (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab
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- Karlsson Sundbaum, Johanna (author)
- Uppsala universitet,Luleå tekniska universitet,Hälsa, medicin och rehabilitering,Department of Medical Sciences, Rheumatology, Uppsala University, SE-751 85, Uppsala, Sweden,Reumatologi,Luleå Univ Technol, Dept Hlth Sci, SE-97187 Luleå, Sweden
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- Wallenberg, Matilda (author)
- Uppsala universitet,Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab,Svensk Dos AB, Box 2, SE-75103 Uppsala, Sweden
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- Kohnke, Hugo (author)
- Uppsala universitet,Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab
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- Baecklund, Eva, 1956- (author)
- Uppsala universitet,Reumatologi
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- Hallberg, Pär, 1974- (author)
- Uppsala universitet,Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab
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- Wadelius, Mia (author)
- Uppsala universitet,Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab
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(creator_code:org_t)
- Future Medicine, 2022
- 2022
- English.
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In: Pharmacogenomics (London). - : Future Medicine. - 1462-2416 .- 1744-8042. ; 23:15, s. 813-820
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Subject headings
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- Aim: A follow-up genome-wide association study (GWAS) in an extended cohort of rheumatoid arthritis (RA) patients starting low-dose methotrexate (MTX) treatment was performed to identify further genetic variants associated with alanine aminotransferase (ALT) elevation. Patients & methods: A GWAS was performed on 346 RA patients. Two outcomes within the first 6 months of MTX treatment were assessed: ALT >1.5-times the upper level of normal (ULN) and maximum level of ALT. Results: SPATA9 (rs72783407) was significantly associated with maximum level of ALT (p = 2.58 × 10-8) and PLCG2 (rs60427389) was tentatively associated with ALT >1.5 × ULN. Conclusion: Associations with SNPs in genes related to male fertility (SPATA9) and inflammatory processes (PLCG2) were identified.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- adverse reactions
- drug-related side effects
- genome-wide association study
- hepatotoxicity
- methotrexate
- pharmacogenetics
- rheumatoid arthritis
- Medicinsk vetenskap
- Medical Science
Publication and Content Type
- ref (subject category)
- art (subject category)
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