Sökning: WFRF:(van Dongen Maarten) >
OTTERS: a powerful ...
OTTERS: a powerful TWAS framework leveraging summary-level reference data
-
- Dai, Qile (författare)
- Department of Biostatistics and Bioinformatics, Emory University School of Public Health, Atlanta, GA, 30322, USA; Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA
-
- Zhou, Geyu (författare)
- Program of Computational Biology and Bioinformatics, Yale University, New Haven, CT, 06511, USA
-
- Zhao, Hongyu (författare)
- Program of Computational Biology and Bioinformatics, Yale University, New Haven, CT, 06511, USA; Department of Biostatistics, Yale School of Public Health, New Haven, CT, 06520, USA
-
visa fler...
-
- Võsa, Urmo (författare)
- Estonian Genome Centre, Institute of Genomics, University of Tartu, 50090, Tartu, Estonia
-
- Franke, Lude (författare)
- Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands; Oncode Institute, 3521 AL, Utrecht, The Netherlands
-
- Battle, Alexis (författare)
- Department of Computer Science, and Departments of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA
-
- Teumer, Alexander (författare)
- Institute for Community Medicine, University Medicine Greifswald, 17489, Greifswald, Germany
-
- Lehtimäki, Terho (författare)
- Department of Clinical Chemistry, Fimlab Laboratories and Finnish Centre for Cardiovascular Disease Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33520, Finland
-
- Raitakari, Olli T. (författare)
- Centre for Population Health Research, University of Turku and Turku University Hospital, 20520, Turku, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520, Turku, Finland; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, 20521, Turku, Finland
-
- Esko, Tõnu (författare)
- Estonian Genome Centre, Institute of Genomics, University of Tartu, 50090, Tartu, Estonia
-
- Agbessi, Mawussé (författare)
- Computational Biology, Ontario Institute for Cancer Research, Toronto, ON, Canada
-
- Ahsan, Habibul (författare)
- Department of Public Health Sciences, University of Chicago, Chicago, IL, USA
-
- Alves, Isabel (författare)
- Computational Biology, Ontario Institute for Cancer Research, Toronto, ON, Canada
-
- Andiappan, Anand Kumar (författare)
- Singapore Immunology Network, Agency for Science Technology and Research, Singapore, Singapore
-
- Arindrarto, Wibowo (författare)
- Leiden University Medical Center, Leiden, The Netherlands
-
- Awadalla, Philip (författare)
- Computational Biology, Ontario Institute for Cancer Research, Toronto, ON, Canada
-
- Battle, Alexis (författare)
- Institute for Community Medicine, University Medicine Greifswald, 17489, Greifswald, Germany
-
- Beutner, Frank (författare)
- Heart Center Leipzig, Universität Leipzig, Leipzig, Germany
-
- Jan Bonder, Marc (författare)
- Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands; European Molecular Biology Laboratory, Genome Biology Unit, 69117, Heidelberg, Germany
-
- Boomsma, Dorret I. (författare)
- Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
-
- Christiansen, Mark W. (författare)
- Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA
-
- Claringbould, Annique (författare)
- Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands; Oncode Institute, 3521 AL, Utrecht, The Netherlands
-
- Deelen, Patrick (författare)
- Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands; Oncode Institute, 3521 AL, Utrecht, The Netherlands; Genomics Coordination Center, University Medical Centre Groningen, Groningen, The Netherlands; Department of Genetics, University Medical Centre Utrecht, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands
-
- Favé, Marie-Julie (författare)
- Computational Biology, Ontario Institute for Cancer Research, Toronto, ON, Canada
-
- Frayling, Timothy (författare)
- Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, UK
-
- Gharib, Sina A. (författare)
- Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA; Department of Medicine, University of Washington, Seattle, WA, USA
-
- Gibson, Greg (författare)
- School of Biological Sciences, Georgia Tech, Atlanta, GA, USA
-
- Heijmans, Bastiaan T. (författare)
- Leiden University Medical Center, Leiden, The Netherlands
-
- Hemani, Gibran (författare)
- MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK
-
- Jansen, Rick (författare)
- Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
-
- Kähönen, Mika (författare)
- Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
-
- Kalnapenkis, Anette (författare)
- Estonian Genome Centre, Institute of Genomics, University of Tartu, 50090, Tartu, Estonia
-
- Kasela, Silva (författare)
- Estonian Genome Centre, Institute of Genomics, University of Tartu, 50090, Tartu, Estonia
-
- Kettunen, Johannes (författare)
- University of Helsinki, Helsinki, Finland
-
- Kim, Yungil (författare)
- Department of Computer Science, and Departments of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA; Genetics and Genomic Science Department, Icahn School of Medicine at Mount Sinai, New York, NY, USA
-
- Kirsten, Holger (författare)
- Institut für Medizinische InformatiK, Statistik und Epidemiologie, LIFE – Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany
-
- Kovacs, Peter (författare)
- IFB Adiposity Diseases, Universität Leipzig, Leipzig, Germany
-
- Krohn, Knut (författare)
- Interdisciplinary Center for Clinical Research, Faculty of Medicine, Universität Leipzig, Leipzig, Germany
-
- Kronberg, Jaanika (författare)
- Estonian Genome Centre, Institute of Genomics, University of Tartu, 50090, Tartu, Estonia
-
- Kukushkina, Viktorija (författare)
- Estonian Genome Centre, Institute of Genomics, University of Tartu, 50090, Tartu, Estonia
-
- Kutalik, Zoltan (författare)
- Lausanne University Hospital, Lausanne, Switzerland
-
- Lee, Bernett (författare)
- Singapore Immunology Network, Agency for Science Technology and Research, Singapore, Singapore
-
- Loeffler, Markus (författare)
- Institut für Medizinische InformatiK, Statistik und Epidemiologie, LIFE – Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany
-
- Marigorta, Urko M. (författare)
- School of Biological Sciences, Georgia Tech, Atlanta, GA, USA; Integrative Genomics Lab, CIC bioGUNE, Bizkaia Science and Technology Park, Derio, Bizkaia, Basque Country, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain
-
- Mei, Hailang (författare)
- Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
-
- Milani, Lili (författare)
- Estonian Genome Centre, Institute of Genomics, University of Tartu, 50090, Tartu, Estonia
-
- Montgomery, Grant W. (författare)
- Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia
-
- Müller-Nurasyid, Martina (författare)
- Institute of Genetic Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany; Department of Medicine I, University Hospital Munich, Ludwig Maximilian’s University, München, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany
-
- Nauck, Matthias (författare)
- Institute of Clinical Chemistry and Laboratory Medicine, Greifswald University Hospital, Greifswald, Germany; German Center for Cardiovascular Research (partner site Greifswald), Greifswald, Germany
-
- Nivard, Michel G. (författare)
- Department of Biological Psychology, Faculty of Behaviour and Movement Sciences, VU, Amsterdam, The Netherlands
-
- Penninx, Brenda (författare)
- Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
-
- Perola, Markus (författare)
- National Institute for Health and Welfare, University of Helsinki, Helsinki, Finland
-
- Pervjakova, Natalia (författare)
- Estonian Genome Centre, Institute of Genomics, University of Tartu, 50090, Tartu, Estonia
-
- Pierce, Brandon L. (författare)
- Department of Public Health Sciences, University of Chicago, Chicago, IL, USA
-
- Powell, Joseph (författare)
- Garvan Institute of Medical Research, Garvan-Weizmann Centre for Cellular Genomics, Sydney, NSW, Australia
-
- Prokisch, Holger (författare)
- Institute of Neurogenomics, Helmholtz Zentrum München, Neuherberg, Germany; Institute of Human Genetics, Technical University Munich, Munich, Germany
-
- Psaty, Bruce M. (författare)
- Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA
-
- Ripatti, Samuli (författare)
- Statistical and Translational Genetics, University of Helsinki, Helsinki, Finland
-
- Rotzschke, Olaf (författare)
- Singapore Immunology Network, Agency for Science Technology and Research, Singapore, Singapore
-
- Rüeger, Sina (författare)
- Lausanne University Hospital, Lausanne, Switzerland
-
- Saha, Ashis (författare)
- Department of Computer Science, and Departments of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA
-
- Scholz, Markus (författare)
- Institut für Medizinische InformatiK, Statistik und Epidemiologie, LIFE – Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany
-
- Schramm, Katharina (författare)
- Institute of Genetic Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany; Department of Medicine I, University Hospital Munich, Ludwig Maximilian’s University, München, Germany
-
- Seppälä, Ilkka (författare)
- Department of Clinical Chemistry, Fimlab Laboratories and Finnish Centre for Cardiovascular Disease Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33520, Finland
-
- Slagboom, Eline P. (författare)
- Leiden University Medical Center, Leiden, The Netherlands
-
- Stehouwer, Coen D. A. (författare)
- Department of Internal Medicine and School for Cardiovascular Diseases (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands
-
- Stumvoll, Michael (författare)
- Department of Medicine, Universität Leipzig, Leipzig, Germany
-
- Sullivan, Patrick (författare)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
-
- ‘t Hoen, Peter A. C. (författare)
- Center for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center Nijmegen, Nijmegen, The Netherlands
-
- Thiery, Joachim (författare)
- Institute for Laboratory Medicine, LIFE – Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany
-
- Tong, Lin (författare)
- Department of Public Health Sciences, University of Chicago, Chicago, IL, USA
-
- Tönjes, Anke (författare)
- German Center for Cardiovascular Research (partner site Greifswald), Greifswald, Germany
-
- van Dongen, Jenny (författare)
- Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
-
- van Iterson, Maarten (författare)
- Leiden University Medical Center, Leiden, The Netherlands
-
- van Meurs, Joyce (författare)
- Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
-
- Veldink, Jan H. (författare)
- UMC Utrecht Brain Center, University Medical Center Utrecht, Department of Neurology, Utrecht University, Utrecht, The Netherlands
-
- Verlouw, Joost (författare)
- Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
-
- Visscher, Peter M. (författare)
- Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia
-
- Völker, Uwe (författare)
- Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany
-
- Westra, Harm-Jan (författare)
- Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands; Oncode Institute, 3521 AL, Utrecht, The Netherlands
-
- Wijmenga, Cisca (författare)
- Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands
-
- Yaghootkar, Hanieh (författare)
- Luleå tekniska universitet,Medicinsk vetenskap,Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, UK; School of Life Sciences, College of Liberal Arts and Science, University of Westminster, 115 New Cavendish Street, London, UK
-
- Yang, Jian (författare)
- Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia; School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China
-
- Zeng, Biao (författare)
- School of Biological Sciences, Georgia Tech, Atlanta, GA, USA
-
- Zhang, Futao (författare)
- Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia
-
- Epstein, Michael P. (författare)
- Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA
-
- Yang, Jingjing (författare)
- Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA
-
visa färre...
-
(creator_code:org_t)
- Springer Nature, 2023
- 2023
- Engelska.
-
Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 14:1
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://ltu.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Most existing TWAS tools require individual-level eQTL reference data and thus are not applicable to summary-level reference eQTL datasets. The development of TWAS methods that can harness summary-level reference data is valuable to enable TWAS in broader settings and enhance power due to increased reference sample size. Thus, we develop a TWAS framework called OTTERS (Omnibus Transcriptome Test using Expression Reference Summary data) that adapts multiple polygenic risk score (PRS) methods to estimate eQTL weights from summary-level eQTL reference data and conducts an omnibus TWAS. We show that OTTERS is a practical and powerful TWAS tool by both simulations and application studies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Nyckelord
- Medical Engineering
- Medicinsk teknik
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Dai, Qile
-
Zhou, Geyu
-
Zhao, Hongyu
-
Võsa, Urmo
-
Franke, Lude
-
Battle, Alexis
-
visa fler...
-
Teumer, Alexande ...
-
Lehtimäki, Terho
-
Raitakari, Olli ...
-
Esko, Tõnu
-
Agbessi, Mawussé
-
Ahsan, Habibul
-
Alves, Isabel
-
Andiappan, Anand ...
-
Arindrarto, Wibo ...
-
Awadalla, Philip
-
Beutner, Frank
-
Jan Bonder, Marc
-
Boomsma, Dorret ...
-
Christiansen, Ma ...
-
Claringbould, An ...
-
Deelen, Patrick
-
Favé, Marie-Juli ...
-
Frayling, Timoth ...
-
Gharib, Sina A.
-
Gibson, Greg
-
Heijmans, Bastia ...
-
Hemani, Gibran
-
Jansen, Rick
-
Kähönen, Mika
-
Kalnapenkis, Ane ...
-
Kasela, Silva
-
Kettunen, Johann ...
-
Kim, Yungil
-
Kirsten, Holger
-
Kovacs, Peter
-
Krohn, Knut
-
Kronberg, Jaanik ...
-
Kukushkina, Vikt ...
-
Kutalik, Zoltan
-
Lee, Bernett
-
Loeffler, Markus
-
Marigorta, Urko ...
-
Mei, Hailang
-
Milani, Lili
-
Montgomery, Gran ...
-
Müller-Nurasyid, ...
-
Nauck, Matthias
-
Nivard, Michel G ...
-
Penninx, Brenda
-
Perola, Markus
-
Pervjakova, Nata ...
-
Pierce, Brandon ...
-
Powell, Joseph
-
Prokisch, Holger
-
Psaty, Bruce M.
-
Ripatti, Samuli
-
Rotzschke, Olaf
-
Rüeger, Sina
-
Saha, Ashis
-
Scholz, Markus
-
Schramm, Kathari ...
-
Seppälä, Ilkka
-
Slagboom, Eline ...
-
Stehouwer, Coen ...
-
Stumvoll, Michae ...
-
Sullivan, Patric ...
-
‘t Hoen, Peter A ...
-
Thiery, Joachim
-
Tong, Lin
-
Tönjes, Anke
-
van Dongen, Jenn ...
-
van Iterson, Maa ...
-
van Meurs, Joyce
-
Veldink, Jan H.
-
Verlouw, Joost
-
Visscher, Peter ...
-
Völker, Uwe
-
Westra, Harm-Jan
-
Wijmenga, Cisca
-
Yaghootkar, Hani ...
-
Yang, Jian
-
Zeng, Biao
-
Zhang, Futao
-
Epstein, Michael ...
-
Yang, Jingjing
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Medicinsk geneti ...
- Artiklar i publikationen
-
Nature Communica ...
- Av lärosätet
-
Luleå tekniska universitet