Functional significance of female sex hormone receptors in the periodontium (Madrid)

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MARC

Jonsson, D (author)

Functional significance of female sex hormone receptors in the periodontium (Madrid)

Article/chapterEnglish2006

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2006
printrdacarrier

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LIBRIS-ID:oai:DiVA.org:mau-12258
https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-12258URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:kon swepub-publicationtype

Notes

Department of Experimental Medical Sciences, Lund University, Sweden. Department of Periodontology, Faculty of Odontology, Malmö University, Sweden. Introduction: Several studies have addressed the association between changes in estrogen and progesterone levels and changes in parameters of periodontitis. The purpose of this project is to investigate the mechanisms by which estrogen influence structure and function of the periodontal ligament by affecting the properties of periodontal ligament cells (PDL cells). Materials and methods: PDL cells were obtained from teeth extracted for orthodontic reasons. The cells were cultured from periodontal tissue explants and used in passages 3-5. Estrogen (ER) and progesterone receptor (PR) expression was investigated by immunocytochemistry. Subcellular distribution of ERβ was determined using mitotracker, immunogoldlabeling and electronmicroscopy. DNA and collagen synthesis was measured using incorporation of radioactive isotopes. Results: ERβ but not ERα or PR immunoreactivity was observed in the PDL cells. Preliminary results show that ERβ is distributed not only in the nucleus but also in the mitochondria and cytosol. Estrogen increased DNA synthesis in human breast cancer cells but had no effect on PDL cell DNA or collagen synthesis. Conclusions: Human PDL cells express ERβ suggesting that estrogen affects PDL cellular function via this ER subtype. Estrogen has no effect on DNA and collagen synthesis, showing that estrogen has no beneficial effect on the periodontium via this mechanism. Instead estrogen via ERβ acts on the periodontium via another still unknown mechanism.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Odontologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Dentistry hsv//eng

Added entries (persons, corporate bodies, meetings, titles ...)

Bratthall, GunillaMalmö högskola,Odontologiska fakulteten (OD) (author)
Wahlin, ÅsaMalmö högskola,Odontologiska fakulteten (OD)(Swepub:mau)odaswa (author)
Nilsson, BO (author)
Malmö högskolaOdontologiska fakulteten (OD) (creator_code:org_t)

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By the author/editor: Jonsson, D; Bratthall, Gunil ...; Wahlin, Åsa; Nilsson, BO

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Dentistry

By the university: Malmö University

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