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Global 13C tracing ...
Global 13C tracing and metabolic flux analysis of intact human liver tissue ex vivo
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- Grankvist, Nina (author)
- Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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- Jönsson, Cecilia (author)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten
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- Hedin, Karin (author)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten
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- Sundqvist, Nicolas (author)
- Linköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten
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- Sandström, Per (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US
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- Björnsson, Bergthor (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US
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- Begzati, Arjana (author)
- Univ Calif San Diego, CA USA
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- Mickols, Evgeniya (author)
- Uppsala universitet,Institutionen för farmaci,Uppsala Univ, Sweden
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- Artursson, Per (author)
- Uppsala universitet,Institutionen för farmaci,Uppsala Univ, Sweden
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- Jain, Mohit (author)
- Univ Calif San Diego, CA USA; Sapient Bioanalyt, CA USA
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- Cedersund, Gunnar (author)
- Linköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten
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- Nilsson, Roland (author)
- Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Nature Metabolism. - : Springer Nature. - 2522-5812.
- Related links:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Liver metabolism is central to human physiology and influences the pathogenesis of common metabolic diseases. Yet, our understanding of human liver metabolism remains incomplete, with much of current knowledge based on animal or cell culture models that do not fully recapitulate human physiology. Here, we perform in-depth measurement of metabolism in intact human liver tissue ex vivo using global 13C tracing, non-targeted mass spectrometry and model-based metabolic flux analysis. Isotope tracing allowed qualitative assessment of a wide range of metabolic pathways within a single experiment, confirming well-known features of liver metabolism but also revealing unexpected metabolic activities such as de novo creatine synthesis and branched-chain amino acid transamination, where human liver appears to differ from rodent models. Glucose production ex vivo correlated with donor plasma glucose, suggesting that cultured liver tissue retains individual metabolic phenotypes, and could be suppressed by postprandial levels of nutrients and insulin, and also by pharmacological inhibition of glycogen utilization. Isotope tracing ex vivo allows measuring human liver metabolism with great depth and resolution in an experimentally tractable system.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Grankvist, Nina
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Jönsson, Cecilia
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Hedin, Karin
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Sundqvist, Nicol ...
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Sandström, Per
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Björnsson, Bergt ...
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show more...
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Begzati, Arjana
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Mickols, Evgeniy ...
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Artursson, Per
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Jain, Mohit
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Cedersund, Gunna ...
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Nilsson, Roland
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Clinical Laborat ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Physiology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmaceutical S ...
- Articles in the publication
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Nature Metabolis ...
- By the university
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Uppsala University
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Linköping University