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Dopamine in plasma :
Dopamine in plasma : a biomarker for myofascial TMD pain?
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- Dawson, Andreas (författare)
- Malmö högskola,Odontologiska fakulteten (OD),Center for Oral Rehabilitation, Östergötland County Council, Linköping, Sweden; Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden; Department of Dentistry, Aarhus University, Aarhus, Denmark,Region Östergötland, Folktandvården,Malmö University, Sweden; Karolinska Institute, Sweden; Malmö University, Sweden; Aarhus University, Denmark
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- Stensson, Niclas (författare)
- Linköpings universitet,Avdelningen för samhällsmedicin,Medicinska fakulteten
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- Ghafouri, Bijar (författare)
- Linköpings universitet,Avdelningen för samhällsmedicin,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum
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- Gerdle, Björn (författare)
- Linköpings universitet,Avdelningen för samhällsmedicin,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum
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- List, Thomas (författare)
- Malmö högskola,Odontologiska fakulteten (OD),Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden; Department of Dentistry, Aarhus University, Aarhus, Denmark; Department of Rehabilitation Medicine, Skåne University Hospital, Lund, Sweden,Malmö University, Sweden; Skåne University Hospital, Sweden; Karolinska Institute, Sweden; Malmö University, Sweden; Aarhus University, Denmark
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- Svensson, Peter (författare)
- Karolinska Institutet,Malmö högskola,Odontologiska fakulteten (OD),Center for Functionally Integrative Neuroscience (CFIN), MindLab, Aarhus University Hospital, Aarhus, Denmark; Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden; Department of Dentistry, Aarhus University, Aarhus, Denmark; Section of Clinical Oral Physiology, Department of Dentistry, Aarhus University, Aarhus, Denmark; Section of Orofacial Pain and Jaw Function, Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden,Aarhus University, Denmark; Aarhus University Hospital, Denmark; Karolinska Institute, Sweden; Karolinska Institute, Sweden; Malmö University, Sweden; Aarhus University, Denmark
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- Ernberg, Malin (författare)
- Karolinska Institutet,Karolinska Institute, Sweden; Karolinska Institute, Sweden; Malmö University, Sweden; Aarhus University, Denmark
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(creator_code:org_t)
- 2016-07-07
- 2016
- Engelska.
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Ingår i: Journal of Headache and Pain. - : Springer. - 1129-2369 .- 1129-2377. ; 17:1
- Relaterad länk:
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https://doi.org/10.1...
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https://mau.diva-por... (primary) (Raw object)
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https://thejournalof...
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Dopaminergic pathways could be involved in the pathophysiology of myofascial temporomandibular disorders (M-TMD). This study investigated plasma levels of dopamine and serotonin (5-HT) in patients with M-TMD and in healthy subjects. METHODS: Fifteen patients with M-TMD and 15 age- and sex-matched healthy subjects participated. The patients had received an M-TMD diagnosis according to the Research Diagnostic Criteria for TMD. Perceived mental stress, pain intensity (0-100-mm visual analogue scale), and pressure pain thresholds (PPT, kPa) over the masseter muscles were assessed; a venous blood sample was taken. RESULTS: Dopamine in plasma differed significantly between patients with M-TMD (4.98 ± 2.55 nM) and healthy controls (2.73 ± 1.24 nM; P < 0.01). No significant difference in plasma 5-HT was observed between the groups (P = 0.75). Patients reported significantly higher pain intensities (P < 0.001) and had lower PPTs (P < 0.01) compared with the healthy controls. Importantly, dopamine in plasma correlated significantly with present pain intensity (r = 0.53, n = 14, P < 0.05) and perceived mental stress (r = 0.34, n = 28, P < 0.05). CONCLUSIONS: The results suggest that peripheral dopamine might be involved in modulating peripheral pain. This finding, in addition to reports in other studies, suggests that dopaminergic pathways could be implicated in the pathophysiology of M-TMD but also in other chronic pain conditions. More research is warranted to elucidate the role of peripheral dopamine in the pathophysiology of chronic pain.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- 5-HT
- Bruxism
- Dopamine
- Masseter muscle
- Temporomandibular joint disorders
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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