Bacterial diversity in medication-related osteonecrosis of the jaw

Hallmer, FredrikMalmö högskola,Odontologiska fakulteten (OD),Department of Oral and Maxillofacial Surgery, Skåne University Hospital, Lund, Sweden (författare)

Objective. The aim was to study the association between microflora and medication-related osteonecrosis of the jaw (MRONJ) by using culture-independent molecular techniques to detect bacteria in necrotic bone lesions. Study Design. Included were 18 consecutive patients with MRONJ, 10 with osteoporosis and 8 cancer patients. Bone biopsies were retrieved from the center of the necrotic bone and from visually healthy bone, and 16 S rRNA gene fragments from bacterial DNA were amplified with polymerase chain reaction. Results. The study revealed a diversity of bacteria represented by 16 S rRNA sequences in all the necrotic bone samples and in 60% of the visually healthy bone. Eight dominating taxa groups were identified at the genus level: Porphyromonas, Lactobacillus, Tannerella, Prevotella, Actinomyces, Treponema, Streptococcus, and Fusobacterium. Conclusions. The necrotic bone lesions contained mainly anaerobic bacteria, representative of periodontal microflora, suggesting that a periodontal infection in combination with antiresorptive treatment could initiate osteonecrosis.

Bjørnland, ToreDepartment of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Oslo, Oslo, Norway (författare)
Andersson, GunillaMalmö högskola,Odontologiska fakulteten (OD)(Swepub:mau)odguan (författare)
Becktor, Jonas PMalmö högskola,Odontologiska fakulteten (OD)(Swepub:mau)odjobe (författare)
Kristoffersen, Anne K.Senior Engineer, Department of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway (författare)
Enersen, MortenDepartment of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway (författare)
Malmö högskolaOdontologiska fakulteten (OD) (creator_code:org_t)

Ingår i:Oral surgery, oral medicine, oral pathology and oral radiology: Elsevier123:4, s. 436-4442212-44032212-4411

Av författaren/redakt...: Hallmer, Fredrik; Bjørnland, Tore; Andersson, Gunil ...; Becktor, Jonas P; Kristoffersen, A ...; Enersen, Morten

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Odontologi

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