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Effects of clinical...
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Pihl, MariaMalmö högskola,Odontologiska fakulteten (OD)
(författare)
Effects of clinical isolates of Pseudomonas aeruginosa on Staphylococcus epidermidis biofilm formation
- Artikel/kapitelEngelska2010
Förlag, utgivningsår, omfång ...
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Wiley-Blackwell,2010
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:mau-15656
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https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-15656URI
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https://doi.org/10.1111/j.1574-695X.2010.00707.xDOI
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https://lup.lub.lu.se/record/1625696URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Pseudomonas aeruginosa is often found in chronic infections, including cystic fibrosis lung infections and those related to chronic wounds and venous ulcers. At the latter sites, P. aeruginosa can be isolated together with Staphylococcus epidermidis, and we have therefore explored the effect of clinical isolates and laboratory strains of P. aeruginosa strains on colonisation by S. epidermidis in dual-species biofilms. Biofilm formation was assayed using 16S rRNA fluorescence in situ hybridization and confocal laser scanning microscopy. Amongst the six P. aeruginosa strains tested, one particular strain, denoted 14:2, exerted a significant inhibitory effect and even after six hours, S. epidermidis levels in dual-species biofilms were reduced by more than 85% compared to biofilms without P. aeruginosa. Interestingly strain 14:2 was found to be negative for classical virulence determinants including pyocyanin, elastase and alkaline protease. Therefore, we suggest that less virulent phenotypes of P. aeruginosa which may develop over time in chronic infections, could counteract colonisation by S. epidermidis, ensuring persistence and dominance by P. aeruginosa in the host micro-habitat. Further studies are required to explain the inhibitory effect on S. epidermidis, although, extracellular polysaccharides produced by P. aeruginosa might play a role in this phenomenon.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Chávez de Paz, Luis Eduardo
(författare)
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Schmidtchen, ArturLund University,Lunds universitet,Dermatologi och venereologi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Dermatology and Venereology (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)derm-asc
(författare)
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Svensäter, GunnelMalmö högskola,Odontologiska fakulteten (OD)(Swepub:mau)odgusv
(författare)
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Davies, JuliaMalmö högskola,Odontologiska fakulteten (OD)(Swepub:mau)odjuda
(författare)
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Malmö högskolaOdontologiska fakulteten (OD)
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:FEMS Immunology and Medical Microbiology: Wiley-Blackwell59:3, s. 504-5120928-82441574-695X
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