Chemically modified titanium-zirconium implants in comparison with commercially pure titanium controls stimulate the early molecular pathways of bone healing

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Galli, SilviaMalmö högskola,Odontologiska fakulteten (OD) (författare)

Chemically modified titanium-zirconium implants in comparison with commercially pure titanium controls stimulate the early molecular pathways of bone healing

Artikel/kapitelEngelska2017

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2016-08-16
Blackwell Munksgaard,2017
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Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:mau-15747
https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-15747URI
https://doi.org/10.1111/clr.12947DOI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:art swepub-publicationtype

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OBJECTIVES: Titanium-zirconium (TiZr) has been proposed as a mechanically stronger alternative to commercially pure titanium for oral and orthopaedic implants. However, not much is known on the osseointegration kinetics of TiZr surfaces. In this study, we aimed to identify the genetic response of bone around TiZr implants compared to pure Ti. MATERIAL AND METHODS: Microtextured and hydrophilic TiZr implants (tests) and cpTi implants grade IV (controls) were placed in the tibia of 30 New Zealand white rabbits. At 2, 4 and 12 weeks, the implants were subjected to removal torque test (RTQ). The expression of a panel of genes involved in the process of osseointegration was measured in the bone around the test and control implants by means of quantitative real-time polymerase chain reaction (PCR) and compared to the control samples. RESULTS: The controls yielded statistically significant higher RTQ at 4 weeks, but the RTQ of the tests had a larger increase between 4 and 12 weeks, when both groups reached similar values. The gene expression analysis showed that all selected markers for bone formation, bone remodelling and cytokines were significantly upregulated around TiZr implants after 2 weeks. After 4 weeks of healing, two bone formation markers were significantly more expressed in the test samples, while at 12 weeks, the expression of all genes was similar in the two groups. CONCLUSIONS: TiZr implants showed comparable biomechanical outcomes to cpTi up to 12 weeks of healing. However, at early healing stages, they showed a significant upregulation of osteogenesis and osteoclastogenesis markers.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Odontologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Dentistry hsv//eng
gene expression
osseointegration
Ti alloys
Ti-Zr
Titanium–zirconium
oral implants
bone healing

Biuppslag (personer, institutioner, konferenser, titlar ...)

Jimbo, RyoMalmö högskola,Odontologiska fakulteten (OD)(Swepub:mau)odryji (författare)
Naito, YoshihitoOral Implant Center, Tokushima University Hospital, Tokushima, Japan(Swepub:mau)ac2883 (författare)
Berner, SimonInstitut Straumann AG, Basel, Switzerland (författare)
Dard, MichelCollege of Dentistry, New York University, New York, NY, USA; Institut Straumann AG, Basel, Switzerland (författare)
Wennerberg, AnnMalmö högskola,Odontologiska fakulteten (OD)(Swepub:mau)odanwe (författare)
Malmö högskolaOdontologiska fakulteten (OD) (creator_code:org_t)

Sammanhörande titlar

Ingår i:Clinical Oral Implants Research: Blackwell Munksgaard28:10, s. 1234-12400905-71611600-0501

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Clinical Oral Implants Research (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: Galli, Silvia; Jimbo, Ryo; Naito, Yoshihito; Berner, Simon; Dard, Michel; Wennerberg, Ann

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Odontologi

Artiklar i publikationen: Clinical Oral Im ...

Av lärosätet: Malmö universitet

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