An Exploratory Case-Control Study on the Impact of IL-1 Gene Polymorphisms on Early Implant Failure

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: (WFRF:(Paul J)) lar1:(mau) > An Exploratory Case...

Cosyn, JanDental Medicine, Faculty of Medicine and Pharmacy, Free University of Brussels, Brussels, Belgium; Department of Periodontology and Oral Implantology, Dental School, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium (författare)

An Exploratory Case-Control Study on the Impact of IL-1 Gene Polymorphisms on Early Implant Failure

Artikel/kapitelEngelska2016

Förlag, utgivningsår, omfång ...

2014-07-26
John Wiley & Sons,2016
printrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:mau-15945
https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-15945URI
https://doi.org/10.1111/cid.12237DOI

Kompletterande språkuppgifter

Språk:engelska
Sammanfattning på:engelska

Ingår i deldatabas

SwePubSwePub

Klassifikation

Ämneskategori:ref swepub-contenttype
Ämneskategori:art swepub-publicationtype

Anmärkningar

Background The association between IL-1 gene polymorphisms and peri-implantitis has been well documented. However, data on the association with early implant failure are scarce. Purpose The objective of this case-control study was to explore the impact of IL-1A (-889), IL-1B (-511), and IL-1B (+3,954) gene polymorphisms on early implant failure in Caucasians Materials and Methods Between September 2004 and August 2007, 461 patients were treated with dental implants at the University Hospital in Ghent, Belgium. Fourteen subjects of this patient group who had experienced one or more early implant failures (within 6 months from implant installation) were recruited as cases. Fourteen controls, matched in terms of age, gender, and smoking habits, with only surviving implants, were selected from the same patient group. Allele and genotype analysis was performed on the basis of a blood sample by Sanger sequencing of polymerase chain reaction products containing the IL-1A (-889), IL-1B (-511), and IL-1B (+3,954) gene polymorphisms Results A significant impact of the IL-1A (-889) T allele (p=.039) and the IL-1B (+3,954) T allele (p=.003) on early implant failure was demonstrated (odds ratios=3.9 and 15.0, respectively). In addition, the genotypic distribution differed significantly between cases and controls for IL-1B (+3,954) (p=.015 ConclusionsThe IL-1B (+3,954) gene polymorphism seems to affect osseointegration. Additional case-control studies in larger patient groups are needed to confirm this observation.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Odontologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Dentistry hsv//eng
case-control study
implant failure
implant survival
interleukin
osseointegration
polymorphism
survival rate

Biuppslag (personer, institutioner, konferenser, titlar ...)

Christiaens, VéroniqueDepartment of Periodontology and Oral Implantology, Dental School, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium (författare)
Koningsveld, VincentDental School, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium (författare)
Coucke, Paul JCenter for Medical Genetics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium (författare)
De Coster, PeterUnit of Oral Development and Applied Oral Histology, PaeCaMed Research Group, Dental School, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium (författare)
De Paepe, AnneCenter for Medical Genetics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium (författare)
De Bruyn, HugoMalmö högskola,Odontologiska fakulteten (OD),Periodontology and Oral Implantology, Dental School, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium (författare)
Dental Medicine, Faculty of Medicine and Pharmacy, Free University of Brussels, Brussels, Belgium; Department of Periodontology and Oral Implantology, Dental School, Faculty of Medicine and Health Sciences, Ghent University, Ghent, BelgiumDepartment of Periodontology and Oral Implantology, Dental School, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium (creator_code:org_t)

Sammanhörande titlar

Ingår i:Clinical Implant Dentistry and Related Research: John Wiley & Sons18:2, s. 234-2401523-08991708-8208

Internetlänk

Hitta via bibliotek

Clinical Implant Dentistry and Related Research (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Cosyn, Jan; Christiaens, Vér ...; Koningsveld, Vin ...; Coucke, Paul J; De Coster, Peter; De Paepe, Anne; visa fler...; De Bruyn, Hugo; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Odontologi

Artiklar i publikationen: Clinical Implant ...

Av lärosätet: Malmö universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se