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The in vivo effect ...
The in vivo effect of P-15 coating on early osseointegration
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Coelho, Paulo G. (author)
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Teixeira, Hellen S. (author)
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Marin, Charles (author)
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Witek, Lukasz (author)
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Tovar, Nick (author)
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Janal, Malvin N. (author)
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- Jimbo, Ryo (author)
- Malmö högskola,Odontologiska fakulteten (OD)
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(creator_code:org_t)
- 2013-09-16
- 2014
- English.
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In: Journal of Biomedical Materials Research. Part B - Applied biomaterials. - : John Wiley & Sons. - 1552-4973 .- 1552-4981. ; 102:3, s. 430-440
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The aim of this study was to evaluate mechanically and morphologically the effect of a specific peptide sequence P-15, when incorporated into implant surfaces. Three types of implants were used for the study: Group A: commercially pure titanium implant (blasted and acid etched) + electrochemical thin calcium phosphate deposition, Group B: commercially pure titanium implant (blasted and acid etched) + electrochemical thin calcium phosphate deposition + P-15 incorporation, and as control, Group C: commercially pure titanium implant (blasted and acid etched). After a topographical characterization, transcortical osteotomies were made, and all implant groups (102 implants per group) were randomly placed bilaterally in the tibiae of adult beagle dogs (n = 24). At, 1, 2, and 4 weeks post-surgery, the animals were sacrificed and the samples were retrieved for removal torque tests, for nano indentation, and for histomorphometrical analysis. The results (mean +/- 95% CI) showed that Group B (34.4 +/- 8.7%) presented statistically higher bone-to-implant contact than the other groups (A = 23.9 +/- 7.8%; C = 21.7 +/- 8.3%) at 1 week, indicating an enhanced osteogenesis due to the peptide incorporation. The results suggested that the incorporation of P-15 to implant surfaces increased its bioactivity and the effects were notable especially in the early stages of the healing process. (c) 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 430-440, 2014.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Keyword
- histomorphometry
- bioactivity
- biomechanics
- in vivo
- peptide
Publication and Content Type
- ref (subject category)
- art (subject category)
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