Sökning: L773:1935 861X OR L773:1876 4754 >
Effect of repetitiv...
Effect of repetitive transcranial magnetic stimulation on altered perception of One's own face
-
- Kothari, Simple Futarmal (författare)
- Department of Dentistry and Oral Health, Aarhus University, Aarhus C, 8000, Denmark; Scandinavian Center for Orofacial Neurosciences (SCON), Denmark; Hammel Neurorehabilitation and University Research Clinic, Hammel, 8450, Denmark
-
- Dagsdóttir, Lilja Kristin (författare)
- Department of Dentistry and Oral Health, Aarhus University, Aarhus C, 8000, Denmark; Scandinavian Center for Orofacial Neurosciences (SCON), Denmark
-
- Kothari, Mohit (författare)
- Department of Clinical Medicine, Aarhus University, Aarhus N, 8200, Denmark; Hammel Neurorehabilitation and University Research Clinic, Hammel, 8450, Denmark
-
visa fler...
-
- Blicher, Jakob Udby (författare)
- CFIN, Department of Clinical Medicine, Aarhus University, Aarhus N, 8200, Denmark
-
- Kumar, Abhishek (författare)
- Karolinska Institutet
-
- Buchholtz, Poul Erik (författare)
- Department for Depression and Anxiety Disorders, Aarhus University Hospital, Aarhus N, 8200, Denmark
-
- Ashkanian, Mahmoud (författare)
- Department for Depression and Anxiety Disorders, Aarhus University Hospital, Aarhus N, 8200, Denmark
-
- Svensson, Peter (författare)
- Malmö universitet,Odontologiska fakulteten (OD),Department of Dentistry and Oral Health, Aarhus University, Aarhus C, 8000, Denmark; Scandinavian Center for Orofacial Neurosciences (SCON), Denmark
-
visa färre...
-
(creator_code:org_t)
- Elsevier, 2020
- 2020
- Engelska.
-
Ingår i: Brain Stimulation. - : Elsevier. - 1935-861X .- 1876-4754. ; 13:3, s. 554-561
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://mau.diva-por... (primary) (Raw object)
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND: Chronic orofacial pain (COP) patients often perceive the painful face area as "swollen" without clinical signs; such self-reported illusions of the face are termed perceptual distortion (PD). The pathophysiological mechanisms underlying PD remain elusive.OBJECTIVE: To test the neuromodulatory effect of repetitive transcranial magnetic stimulation (rTMS) on PD in healthy individuals, to gain insight into the cortical mechanisms underlying PD.METHODS: PD was induced experimentally by injections of local anesthetic (LA) around the infraorbital nerve and measured as perceived size changes of the affected area. Participants were randomly allocated to inhibitory rTMS (n = 26) or sham rTMS (n = 26) group. The participants rated PD at baseline, 6 min after LA, immediately, 20 and 40 min after rTMS. The rTMS (inhibitory and sham) was applied to face (lip) representation area of primary somatosensory cortex (SI) as an intervention at 10 min after the LA, when the magnitude of PD is large. As inhibitory rTMS, continuous theta-burst stimulation paradigm (50 Hz) for 40s was employed to inhibit cortical activity.RESULTS: We demonstrated a significant decrease in the magnitude of PD immediately and 20 min after the application of inhibitory rTMS compared with sham rTMS (P < 0.006). In two control experiments, we also showed that peripheral muscle stimulation and stimulation of a cortical region other than the lip representation area had no effect on the magnitude of the PD.CONCLUSIONS: Inhibitory rTMS applied to a somatotopical-relevant cortical region modulates PD of the face in healthy individuals and could potentially have therapeutic implications for COP patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Local anesthesia
- Orofacial pain
- Perceptual distortion of face
- Primary somatosensory cortex
- Repetitive transcranial magnetic stimulation
- Theta-burst stimulation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas