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  • Devito, CDepartment of Clinical Virology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden; Department of Virology, Swedish Institute for Infectious Disease Control, Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden (author)

Cross-Clade HIV-1-Specific Neutralizing IgA in Mucosal and Systemic Compartments of HIV-1-Exposed, Persistently Seronegative Subjects

  • Article/chapterEnglish2002

Publisher, publication year, extent ...

  • Lippincott Williams & Wilkins,2002
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:mau-4442
  • https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-4442URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:1955243URI
  • https://doi.org/10.1097/00042560-200208010-00007DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • There is an urgent need for a universally effective HIV-1 vaccine, but whether a vaccine will be able to protect against HIV-1 of different clades is a significant concern. IgA from HIV-1-exposed, persistently seronegative (HEPS) subjects has been shown to neutralize HIV-1 and to block epithelial HIV-1 transcytosis, and it may target novel HIV-1 epitopes. We have tested the ability of plasma and mucosal IgA purified from HEPS subjects to neutralize HIV-1 primary isolates of different viral clades and phenotypes. IgA from two groups of HEPS subjects was tested: sex workers from Nairobi, Kenya, where clades A and D predominate, and the heterosexual partners of individuals infected by clade B virus. HIV-1-infected and low-risk uninfected individuals were included as controls. IgA purified from the blood, genital tract, and saliva of most HEPS sex workers demonstrated significant crossclade HIV-1 neutralization, whereas a more clade-restricted pattern of neutralization was found in partners of clade B-infected individuals. IgA purified from HIV-1-infected individuals also mediated cross-clade neutralization, whereas IgA from uninfected controls lacked neutralizing activity. In conclusion, mucosal and plasma IgA from HEPS subjects neutralizes HIV-1 of different clades. This ability to induce HIV-1-specific systemic and mucosal IgA may be an important feature of an effective prophylactic HIV-1 vaccine.

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  • Hinkula, JMalmö högskola,Fakulteten för hälsa och samhälle (HS),Department of Virology, Swedish Institute for Infectious Disease Control, Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden (author)
  • Kaul, RDepartment of Medical Microbiology, University of Nairobi, Nairobi, Kenya (author)
  • Kimani, JDepartment of Medical Microbiology, University of Nairobi, Nairobi, Kenya (author)
  • Kiama, PDepartment of Medical Microbiology, University of Nairobi, Nairobi, Kenya (author)
  • Lopalco, LImmunobiology of HIV Unit, San Raffaele Scientific Institute, Milan, Italy (author)
  • Barass, CImmunobiology of HIV Unit, San Raffaele Scientific Institute, Milan, Italy (author)
  • Piconi, SDivision of Infectious Diseases, L. Sacco Hospital, Milan, Italy (author)
  • Trabattoni, DDepartment of Immunology, University of Milan, Milan, Italy (author)
  • Bwayo, JJDepartment of Medical Microbiology, University of Nairobi, Nairobi, Kenya (author)
  • Plummer, FDepartment of Medical Microbiology, University of Nairobi, Nairobi, Kenya; Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada (author)
  • Clerici, MDepartment of Immunology, University of Milan, Milan, Italy (author)
  • Broliden, KKarolinska Institutet (author)
  • Department of Clinical Virology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden; Department of Virology, Swedish Institute for Infectious Disease Control, Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, SwedenFakulteten för hälsa och samhälle (HS) (creator_code:org_t)

Related titles

  • In:Journal of Acquired Immune Deficiency Syndromes: Lippincott Williams & Wilkins30:4, s. 413-4201525-41351944-7884

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