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Cross-Clade HIV-1-S...
Cross-Clade HIV-1-Specific Neutralizing IgA in Mucosal and Systemic Compartments of HIV-1-Exposed, Persistently Seronegative Subjects
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- Devito, C (författare)
- Department of Clinical Virology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden; Department of Virology, Swedish Institute for Infectious Disease Control, Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
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- Hinkula, J (författare)
- Malmö högskola,Fakulteten för hälsa och samhälle (HS),Department of Virology, Swedish Institute for Infectious Disease Control, Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
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- Kaul, R (författare)
- Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya
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- Kimani, J (författare)
- Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya
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- Kiama, P (författare)
- Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya
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- Lopalco, L (författare)
- Immunobiology of HIV Unit, San Raffaele Scientific Institute, Milan, Italy
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- Barass, C (författare)
- Immunobiology of HIV Unit, San Raffaele Scientific Institute, Milan, Italy
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- Piconi, S (författare)
- Division of Infectious Diseases, L. Sacco Hospital, Milan, Italy
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- Trabattoni, D (författare)
- Department of Immunology, University of Milan, Milan, Italy
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- Bwayo, JJ (författare)
- Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya
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- Plummer, F (författare)
- Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya; Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
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- Clerici, M (författare)
- Department of Immunology, University of Milan, Milan, Italy
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- Broliden, K (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Lippincott Williams & Wilkins, 2002
- 2002
- Engelska.
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Ingår i: Journal of Acquired Immune Deficiency Syndromes. - : Lippincott Williams & Wilkins. - 1525-4135 .- 1944-7884. ; 30:4, s. 413-420
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https://journals.lww...
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https://urn.kb.se/re...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- There is an urgent need for a universally effective HIV-1 vaccine, but whether a vaccine will be able to protect against HIV-1 of different clades is a significant concern. IgA from HIV-1-exposed, persistently seronegative (HEPS) subjects has been shown to neutralize HIV-1 and to block epithelial HIV-1 transcytosis, and it may target novel HIV-1 epitopes. We have tested the ability of plasma and mucosal IgA purified from HEPS subjects to neutralize HIV-1 primary isolates of different viral clades and phenotypes. IgA from two groups of HEPS subjects was tested: sex workers from Nairobi, Kenya, where clades A and D predominate, and the heterosexual partners of individuals infected by clade B virus. HIV-1-infected and low-risk uninfected individuals were included as controls. IgA purified from the blood, genital tract, and saliva of most HEPS sex workers demonstrated significant crossclade HIV-1 neutralization, whereas a more clade-restricted pattern of neutralization was found in partners of clade B-infected individuals. IgA purified from HIV-1-infected individuals also mediated cross-clade neutralization, whereas IgA from uninfected controls lacked neutralizing activity. In conclusion, mucosal and plasma IgA from HEPS subjects neutralizes HIV-1 of different clades. This ability to induce HIV-1-specific systemic and mucosal IgA may be an important feature of an effective prophylactic HIV-1 vaccine.
Ämnesord
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
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Devito, C
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Hinkula, J
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Kaul, R
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Kimani, J
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Kiama, P
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Lopalco, L
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visa fler...
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Barass, C
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Piconi, S
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Trabattoni, D
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Bwayo, JJ
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Plummer, F
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Clerici, M
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Broliden, K
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visa färre...
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Malmö universitet
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Karolinska Institutet