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Cross-Clade HIV-1-S...
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Devito, CDepartment of Clinical Virology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden; Department of Virology, Swedish Institute for Infectious Disease Control, Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
(author)
Cross-Clade HIV-1-Specific Neutralizing IgA in Mucosal and Systemic Compartments of HIV-1-Exposed, Persistently Seronegative Subjects
- Article/chapterEnglish2002
Publisher, publication year, extent ...
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Lippincott Williams & Wilkins,2002
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:mau-4442
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https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-4442URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1955243URI
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https://doi.org/10.1097/00042560-200208010-00007DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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There is an urgent need for a universally effective HIV-1 vaccine, but whether a vaccine will be able to protect against HIV-1 of different clades is a significant concern. IgA from HIV-1-exposed, persistently seronegative (HEPS) subjects has been shown to neutralize HIV-1 and to block epithelial HIV-1 transcytosis, and it may target novel HIV-1 epitopes. We have tested the ability of plasma and mucosal IgA purified from HEPS subjects to neutralize HIV-1 primary isolates of different viral clades and phenotypes. IgA from two groups of HEPS subjects was tested: sex workers from Nairobi, Kenya, where clades A and D predominate, and the heterosexual partners of individuals infected by clade B virus. HIV-1-infected and low-risk uninfected individuals were included as controls. IgA purified from the blood, genital tract, and saliva of most HEPS sex workers demonstrated significant crossclade HIV-1 neutralization, whereas a more clade-restricted pattern of neutralization was found in partners of clade B-infected individuals. IgA purified from HIV-1-infected individuals also mediated cross-clade neutralization, whereas IgA from uninfected controls lacked neutralizing activity. In conclusion, mucosal and plasma IgA from HEPS subjects neutralizes HIV-1 of different clades. This ability to induce HIV-1-specific systemic and mucosal IgA may be an important feature of an effective prophylactic HIV-1 vaccine.
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Hinkula, JMalmö högskola,Fakulteten för hälsa och samhälle (HS),Department of Virology, Swedish Institute for Infectious Disease Control, Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
(author)
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Kaul, RDepartment of Medical Microbiology, University of Nairobi, Nairobi, Kenya
(author)
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Kimani, JDepartment of Medical Microbiology, University of Nairobi, Nairobi, Kenya
(author)
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Kiama, PDepartment of Medical Microbiology, University of Nairobi, Nairobi, Kenya
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Lopalco, LImmunobiology of HIV Unit, San Raffaele Scientific Institute, Milan, Italy
(author)
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Barass, CImmunobiology of HIV Unit, San Raffaele Scientific Institute, Milan, Italy
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Piconi, SDivision of Infectious Diseases, L. Sacco Hospital, Milan, Italy
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Trabattoni, DDepartment of Immunology, University of Milan, Milan, Italy
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Bwayo, JJDepartment of Medical Microbiology, University of Nairobi, Nairobi, Kenya
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Plummer, FDepartment of Medical Microbiology, University of Nairobi, Nairobi, Kenya; Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
(author)
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Clerici, MDepartment of Immunology, University of Milan, Milan, Italy
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Broliden, KKarolinska Institutet
(author)
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Department of Clinical Virology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden; Department of Virology, Swedish Institute for Infectious Disease Control, Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, SwedenFakulteten för hälsa och samhälle (HS)
(creator_code:org_t)
Related titles
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In:Journal of Acquired Immune Deficiency Syndromes: Lippincott Williams & Wilkins30:4, s. 413-4201525-41351944-7884
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Devito, C
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Hinkula, J
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Kaul, R
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Kimani, J
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Kiama, P
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Lopalco, L
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Barass, C
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Piconi, S
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Trabattoni, D
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Bwayo, JJ
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Plummer, F
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Clerici, M
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Broliden, K
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Microbiology
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Journal of Acqui ...
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Malmö University
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Karolinska Institutet