Bioadhesive Lipid Compositions: Self-Assembly Structures, Functionality, and Medical Applications

Barauskas, JustasMalmö högskola,Institutionen för biomedicinsk vetenskap (BMV) (författare)

Bioadhesive Lipid Compositions : Self-Assembly Structures, Functionality, and Medical Applications

Lipid-based liquid crystalline compositions of phospholipids and diglycerides have unique bioadhesive properties with several medical applications, as exemplified by a lipid-based medical device indicated for management and relief of intraoral pain. The present paper describes the relation between self-assembly properties of phosphatidyl choline (PC) and glycerol dioleate (GDO) mixtures in the presence of aqueous fluids and functional attributes of the system, including: film formation and bioadhesion, intraoral coverage, acceptance by patients, and potential as a drug delivery system. The phase behavior of PC/GDO was characterized using synchrotron small-angle X-ray scattering. Functional properties, including the presence of study formulations at intraoral surfaces, ease of attachment, taste, and degree of and intraoral pain, were assessed in a crossover clinical pilot study in head and neck cancer patients. An optimum in functional properties was indicated for formulations with a PC/GDO weight ratio of about 35/65, where the lipids form a reversed cubic liquid crystalline micellar phase structure (Fd3m space group) over the relevant temperature range (25-40 degrees C).

Christerson, Lars (författare)
Wadsäter, MariaLund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)fkem-mrw (författare)
Lindström, Fredrick (författare)
Lindqvist, Anna-Karin (författare)
Tiberg, FredrikLund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)fk1-fti (författare)
Malmö högskolaInstitutionen för biomedicinsk vetenskap (BMV) (creator_code:org_t)

Ingår i:Molecular Pharmaceutics: American Chemical Society (ACS)11:3, s. 895-9031543-83841543-8392

Av författaren/redakt...: Barauskas, Justa ...; Christerson, Lar ...; Wadsäter, Maria; Lindström, Fredr ...; Lindqvist, Anna- ...; Tiberg, Fredrik

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Farmaceutiska ve ...

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