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Search: AMNE:(MEDICAL AND HEALTH SCIENCES) AMNE:(Medical Biotechnology) AMNE:(Biomaterials Science) > Multimodal ex vivo ...

  • Peruzzi, NiccolòLund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine (author)

Multimodal ex vivo methods reveal that Gd-rich corrosion byproducts remain at the implant site of biodegradable Mg-Gd screws

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • Elsevier,2021
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:mau-46879
  • https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-46879URI
  • https://doi.org/10.1016/j.actbio.2021.09.047DOI
  • https://lup.lub.lu.se/record/7035c16b-2e90-44e3-a5c2-164de43ea779URI
  • https://gup.ub.gu.se/publication/311147URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Extensive research is being conducted on magnesium (Mg) alloys for bone implant manufacturing, due to their biocompatibility, biodegradability and mechanical properties. Gadolinium (Gd) is among the most promising alloying elements for property control in Mg alloy implants; however, its toxicity is controversial. Investigating Gd behavior during implant corrosion is thus of utmost importance. In this study, we analyzed the degradation byproducts at the implant site of biodegradable Mg-5Gd and Mg-10Gd implants after 12 weeks healing time, using a combination of different imaging techniques: histology, energy-dispersive x-ray spectroscopy (EDX), x-ray microcomputed tomography (µCT) and neutron µCT. The main finding has been that, at the healing time in exam, the corrosion appears to have involved only the Mg component, which has been substituted by calcium and phosphorus, while the Gd remains localized at the implant site. This was observed in 2D by means of EDX maps and extended to 3D with a novel application of neutron tomography. X-ray fluorescence analysis of the main excretory organs also did not reveal any measurable accumulation of Gd, further reinforcing the conclusion that very limited or no removal at all of Gd-alloy happened during degradation.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Galli, SilviaMalmö University,Malmö universitet,Odontologiska fakulteten (OD),Biofilms Research Center for Biointerfaces(Swepub:mau)ac0585 (author)
  • Helmholz, HeikeHelmholtz-Zentrum hereon GmbH, Germany,Helmholtz-Zentrum Geesthacht (author)
  • Kardjilov, NikolayHelmholtz Centre for Materials and Energy, Germany,Helmholtz-Zentrum Berlin für Materialien und Energie GmbH (author)
  • Krüger, DianaHelmholtz-Zentrum hereon GmbH, Germany,Helmholtz-Zentrum Geesthacht (author)
  • Markötter, HenningBundesanstalt für Materialforschung und-prüfung, Germany,Federal Institute for Material Research and Testing (BAM) Germany (author)
  • Moosmann, JulianHelmholtz-Zentrum hereon GmbH, Germany,Helmholtz-Zentrum Geesthacht (author)
  • Orlov, DmytroLund University,Lunds universitet,Materialteknik,Institutionen för maskinvetenskaper,Institutioner vid LTH,Lunds Tekniska Högskola,Materials Engineering,Department of Mechanical Engineering Sciences,Departments at LTH,Faculty of Engineering, LTH(Swepub:lu)mate-dol (author)
  • Prgomet, ZdenkaMalmö University,Malmö universitet,Odontologiska fakulteten (OD)(Swepub:lu)med-znp (author)
  • Willumeit-Römer, RegineHelmholtz-Zentrum hereon GmbH, Germany,Helmholtz-Zentrum Geesthacht (author)
  • Wennerberg, Ann,1955Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för odontologi, sektion 2,Institute of Odontology, Section 2(Swepub:gu)xwenan (author)
  • Bech, MartinLund University,Lunds universitet,X-ray Phase Contrast,Forskargrupper vid Lunds universitet,Lund University Research Groups(Swepub:lu)med-mbh (author)
  • Medicinsk strålningsfysik, LundSektion V (creator_code:org_t)

Related titles

  • In:Acta Biomaterialia: Elsevier136, s. 582-5911742-70611878-7568

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