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Quantitative detect...
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Gudmundsson, PetriMalmö högskola,Fakulteten för hälsa och samhälle (HS)
(författare)
Quantitative detection of myocardial ischaemia by stress echocardiography; a comparison with SPECT
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
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2009-06-18
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BioMed Central,2009
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electronicrdacarrier
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LIBRIS-ID:oai:DiVA.org:mau-4731
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https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-4731URI
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https://doi.org/10.1186/1476-7120-7-28DOI
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https://lup.lub.lu.se/record/1460082URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:119146896URI
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Språk:engelska
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Sammanfattning på:engelska
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Aims: Real-time perfusion (RTP) adenosine stress echocardiography (ASE) can be used to visually evaluate myocardial ischaemia. The RTP power modulation technique angio-mode (AM), provides images for off-line perfusion quantification using Qontrast® software, generating values of peak signal intensity (A), myocardial blood flow velocity (β) and myocardial blood flow (Axβ). By comparing rest and stress values, their respective reserve values (A-r, β-r, Axβ-r) are generated. We evaluated myocardial ischaemia by RTP-ASE Qontrast® quantification, compared to visual perfusion evaluation with 99mTc-tetrofosmin singlephoton emission computed tomography (SPECT). Methods and Results: Patients admitted to SPECT underwent RTP-ASE (SONOS 5500) using AM during Sonovue® infusion, before and throughout adenosine stress, also used for SPECT. Visual myocardial perfusion and wall motion analysis, and Qontrast® quantification, were blindly compared to one another and to SPECT, at different time points off-line. We analyzed 201 coronary territories (left anterior descendent [LAD], left circumflex [LCx] and right coronary [RCA] artery territories) in 67 patients. SPECT showed ischaemia in 18 patients and 19 territories. Receiver operator characteristics and kappa values showed significant agreement with SPECT only for β-r and Axβ-r in all segments: area under the curve 0.678 and 0.665; P < 0.001 and < 0.01, respectively. The closest agreements were seen in the LAD territory: kappa 0.442 for both β-r and Axβ- r; P < 0.01. Visual evaluation of ischaemia showed good agreement with SPECT: accuracy 93%; kappa 0.67; P < 0.001; without non-interpretable territories. Conclusion: In this agreement study with SPECT, RTP-ASE Qontrast® quantification of myocardial ischaemia was less accurate and less feasible than visual evaluation and needs further development to be clinically useful.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Shahgaldi, Kambiz
(författare)
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Winter, ReidarKarolinska Institutet
(författare)
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Dencker, MagnusLund University,Lunds universitet,Klinisk fysiologi och nuklearmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Physiology and Nuclear Medicine, Malmö,Lund University Research Groups(Swepub:lu)klin-mde
(författare)
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Kitlinski, MariuszLund University,Lunds universitet,Obstetrisk, gynekologisk och prenatal ultraljudsdiagnostik,Forskargrupper vid Lunds universitet,Obstetric, Gynaecological and Prenatal Ultrasound Research,Lund University Research Groups(Swepub:lu)med-mzk
(författare)
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Thorsson, OlaLund University,Lunds universitet,Klinisk fysiologi och nuklearmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Physiology and Nuclear Medicine, Malmö,Lund University Research Groups(Swepub:lu)klin-oth
(författare)
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Willenheimer, Ronnie
(författare)
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Ljunggren, LennartMalmö högskola,Fakulteten för hälsa och samhälle (HS)(Swepub:mau)hslelj
(författare)
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Malmö högskolaFakulteten för hälsa och samhälle (HS)
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Cardiovascular Ultrasound: BioMed Central7:281476-7120
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