id:"swepub:oai:DiVA.org:mau-47819"
Sökning: id:"swepub:oai:DiVA.org:mau-47819" > Comprehensive multi...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
- Buchanan, ClaireLa Trobe Univ, Dept Chem & Phys, Bundoora, Vic, Australia. (författare)
Comprehensive multidimensional study of the self-assembly properties of a three residue substituted beta(3) oligoamide
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
- 2021-10-19
- Walter de Gruyter,2021
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:mau-47819
- https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-47819URI
- https://doi.org/10.1515/pac-2021-0324DOI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- Substituted (beta(3) oligoamides form a unique self-assembling system where each monomer folds into a helix containing approximately three (beta(3) amino acids per turn, yielding a geometrically well-defined cylindrical building block that, when N-acylated, is able to self-assemble head-to-tail into nanorods that can reach several 100 mu m length. It was shown in previous works that self-assembly can be achieved with a three residue long oligoamide as well that lacks any intramolecular H-bonds, yet it crystallizes in a helix-like conformation. The self-assembly properties of these small oligoamides are however elusive, suggesting a more complex system than the self-assembly of the H-bond stabilized helical monomers. Here we focus on the self-assembly behaviour of a three residue oligoamide, Ac-beta(3)[LIA] where the letters denote the side chain of the analogous a amino acid. Ac-beta(3)[LIA] can yield highly inhomogeneous suspensions in water with a broad range of large fibrous structures that seem to be very stable, yet occasionally fibre growth is only observed upon heating. The small size of the monomer suggests a highly dynamic equilibrium yet all previous attempts failed to clearly identify low molecular weight species. Therefore a special methodology was employed in this study to characterize the suspensions at different size ranges: SANS that is optimal to measure the small oligomers and cross sectional diameter of the assemblies, DLS that is sensitive to the large populations and therefore the length of the superstructures, and NMR that is sensitive to monomeric and small oligomeric form, in conjunction with IR spectroscopy to probe the folding and AFM to image the morphology of the assemblies. Temperature ramping was used to perturb the system to probe the dynamicity of the self-assembly. It was found that the anomalous self-assembly behaviour of Ac-beta(3)[LIA] is caused by its two stable conformations, a helix-building "horseshoe" fold and a linear conformer. The latter is exclusively found in monomeric form in solution whereas the horseshoe fold is stable in solid phase and in fibrous assemblies. Small oligomers were absent. Thus the self assembly of Ac-beta(3)[LIA] is arrested by the activation energy need of the conformation change; fibre growth might be triggered by conditions that allow increased conformational freedom of the monomers. This observation may be used to develop strategies for controlled switchable self-assembly.
Ämnesord och genrebeteckningar
- NATURVETENSKAP Biologi Biokemi och molekylärbiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Biochemistry and Molecular Biology hsv//eng
- 14-helix
- NICE 2020
- beta(3) peptides
- spontaneous assembly
- substituted oligoamides
- temperature
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Hinds, Mark G.Univ Melbourne, Bio21 Mol Sci & Biotechnol Inst, Parkville, Vic, Australia. (författare)
- Puskar, LjiljanaHelmholtz Zentrum Berlin Mat & Energie GmbH, Berlin, Germany. (författare)
- Garvey, Christopher J.Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces,Lund Inst Adv Neutron & Xray Sci, S-22370 Lund, Sweden.(Swepub:mau)aj7319 (författare)
- Mechler, AdamLa Trobe Univ, Dept Chem & Phys, Bundoora, Vic, Australia. (författare)
- La Trobe Univ, Dept Chem & Phys, Bundoora, Vic, Australia.Univ Melbourne, Bio21 Mol Sci & Biotechnol Inst, Parkville, Vic, Australia. (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Pure and Applied Chemistry: Walter de Gruyter93:11, s. 1327-13410033-45451365-3075
Internetlänk
Hitta via bibliotek
- Pure and Applied Chemistry (Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Buchanan, Claire
- Hinds, Mark G.
- Puskar, Ljiljana
- Garvey, Christop ...
- Mechler, Adam
- Om ämnet
-
- NATURVETENSKAP
- NATURVETENSKAP
- och Biologi
- och Biokemi och mole ...
- Artiklar i publikationen
- Pure and Applied ...
- Av lärosätet
- Malmö universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
