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  • Attauabi, MohamedDepartment of Gastroenterology and Hepatology, Herlev Hospital, Herlev, Denmark (author)

Influence of Genetics, Immunity and the Microbiome on the Prognosis of Inflammatory Bowel Disease (IBD Prognosis Study) : the protocol for a Copenhagen IBD Inception Cohort Study

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-06-27
  • BMJ Publishing Group Ltd,2022
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:mau-53857
  • https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-53857URI
  • https://doi.org/10.1136/bmjopen-2021-055779DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Introduction: Inflammatory bowel diseases (IBD), encompassing Crohn's disease and ulcerative colitis, are chronic, inflammatory diseases of the gastrointestinal tract. We have initiated a Danish population-based inception cohort study aiming to investigate the underlying mechanisms for the heterogeneous course of IBD, including need for, and response to, treatment.Methods and analysis: IBD Prognosis Study is a prospective, population-based inception cohort study of unselected, newly diagnosed adult, adolescent and paediatric patients with IBD within the uptake area of Hvidovre University Hospital and Herlev University Hospital, Denmark, which covers approximately 1 050 000 inhabitants (~20% of the Danish population). The diagnosis of IBD will be according to the Porto diagnostic criteria in paediatric and adolescent patients or the Copenhagen diagnostic criteria in adult patients. All patients will be followed prospectively with regular clinical examinations including ileocolonoscopies, MRI of the small intestine, validated patient-reported measures and objective examinations with intestinal ultrasound. In addition, intestinal biopsies from ileocolonoscopies, stool, rectal swabs, saliva samples, swabs of the oral cavity and blood samples will be collected systematically for the analysis of biomarkers, microbiome and genetic profiles. Environmental factors and quality of life will be assessed using questionnaires and, when available, automatic registration of purchase data. The occurrence and course of extraintestinal manifestations will be evaluated by rheumatologists, dermatologists and dentists, and assessed by MR cholangiopancreatography, MR of the spine and sacroiliac joints, ultrasonography of peripheral joints and entheses, clinical oral examination, as well as panoramic radiograph of the jaws. Fibroscans and dual-energy X-ray absorptiometry scans will be performed to monitor occurrence and course of chronic liver diseases, osteopenia and osteoporosis.Ethics and dissemination: This study has been approved by Ethics Committee of the Capital Region of Denmark (approval number: H-20065831). Study results will be disseminated through publication in international scientific journals and presentation at (inter)national conferences.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Madsen, Gorm RoagerCopenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, Hvidovre, Denmark (author)
  • Bendtsen, FlemmingGastrounit, Medical Section, Hvidovre Hospital, Hvidovre, Denmark (author)
  • Wewer, Anne VibekeThe Paediatric Department, Hvidovre Hospital, Hvidovre, Denmark (author)
  • Wilkens, RuneGastrounit, Medical Section, Hvidovre Hospital, Hvidovre, Denmark (author)
  • Ilvemark, JohanDepartment of Gastroenterology and Hepatology, Herlev Hospital, Herlev, Denmark (author)
  • Vladimirova, NoraCopenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark (author)
  • Jensen, Annette BøjerDepartment of Radiology, Centre for Functional and Diagnostic Imaging and Research, Hvidovre Hospital, Hvidovre, Denmark (author)
  • Jensen, Frank KriegerDepartment of Radiology, Centre for Functional and Diagnostic Imaging and Research, Hvidovre Hospital, Hvidovre, Denmark (author)
  • Hansen, Sanja BayDepartment of Radiology, Centre for Functional and Diagnostic Imaging and Research, Hvidovre Hospital, Hvidovre, Denmark (author)
  • Siebner, Hartwig RomanDanish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Hvidovre Hospital, Hvidovre, Denmark (author)
  • Nielsen, Yousef Jesper WirenfeldtDepartment of Radiology, Herlev Hospital, Herlev, Denmark (author)
  • Møller, Jakob MDepartment of Radiology, Herlev Hospital, Herlev, Denmark (author)
  • Thomsen, Henrik SDepartment of Radiology, Herlev Hospital, Herlev, Denmark (author)
  • Thomsen, Simon FrancisDepartment of Dermatology, Bispebjerg Hospital, Kobenhavn, Denmark (author)
  • Ingels, Helene Andrea SinclairDepartment of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Kobenhavn, Denmark (author)
  • Theede, KlausGastrounit, Medical Section, Hvidovre Hospital, Hvidovre, Denmark (author)
  • Boysen, TrineGastrounit, Medical Section, Hvidovre Hospital, Hvidovre, Denmark (author)
  • Bjerrum, Jacob TDepartment of Gastroenterology and Hepatology, Herlev Hospital, Herlev, Denmark (author)
  • Jakobsen, ChristianCopenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, Hvidovre, Denmark (author)
  • Dorn-Rasmussen, MariaCopenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, Hvidovre, Denmark (author)
  • Jansson, SabineCopenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, Hvidovre, Denmark (author)
  • Yao, YiqiuDepartment of Dermatology, Bispebjerg Hospital, Kobenhavn, Denmark (author)
  • Burian, Ewa AnnaDepartment of Dermatology, Bispebjerg Hospital, Kobenhavn, Denmark (author)
  • Møller, Frederik TrierDepartment of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Kobenhavn, Denmark (author)
  • Fana, ViktoriaCopenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Kobenhavn, Denmark (author)
  • Wiell, CharlotteCopenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Kobenhavn, Denmark (author)
  • Terslev, LeneCopenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet Glostrup, Glostrup, Denmark (author)
  • Østergaard, MikkelCopenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Kobenhavn, Denmark (author)
  • Bertl, KristinaMalmö universitet,Odontologiska fakulteten (OD),Periodontology(Swepub:mau)ae0620 (author)
  • Stavropoulos, AndreasMalmö universitet,Odontologiska fakulteten (OD),Periodontology(Swepub:mau)ac3062 (author)
  • Seidelin, Jakob BDepartment of Gastroenterology and Hepatology, Herlev Hospital, Herlev, Denmark (author)
  • Burisch, JohanCopenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, Hvidovre, Denmark (author)
  • Department of Gastroenterology and Hepatology, Herlev Hospital, Herlev, DenmarkCopenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, Hvidovre, Denmark (creator_code:org_t)

Related titles

  • In:BMJ Open: BMJ Publishing Group Ltd12:6, s. e055779-e0557792044-6055

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