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Nocebo response in ...
Nocebo response in dentistry : A systematic review and meta-analysis of adverse events in analgesic trials of third molar removal
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- Watanabe, Takeshi (författare)
- Aarhus Univ, Sch Business & Social Sci, Dept Psychol & Behav Sci, Aarhus, Denmark.;Tokushima Univ, Dept Prevent Med, Grad Sch Biomed Sci, Tokushima, Japan.;Tokushima Univ, Dept Prevent Med, Grad Sch Biomed Sci, 3-18-15 Kuramoto Cho, Tokushima 7708503, Japan.
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- Sieg, Mette (författare)
- Aarhus Univ, Sch Business & Social Sci, Dept Psychol & Behav Sci, Aarhus, Denmark.
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- Lunde, Sigrid Juhl (författare)
- Aarhus Univ, Sch Business & Social Sci, Dept Psychol & Behav Sci, Aarhus, Denmark.
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- Persson, Mads (författare)
- Aarhus Univ, Sch Business & Social Sci, Dept Psychol & Behav Sci, Aarhus, Denmark.
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- Taneja, Pankaj (författare)
- Aarhus Univ, Dept Dent & Oral Hlth, Sect Oral & Maxillofacial Surg & Oral Pathol, Aarhus, Denmark.;Scandinavian Ctr Orofacial Neurosci, Aarhus, Denmark.;Scandinavian Ctr Orofacial Neurosci, Malmö, Sweden.
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- Baad-Hansen, Lene (författare)
- Scandinavian Ctr Orofacial Neurosci, Aarhus, Denmark.;Scandinavian Ctr Orofacial Neurosci, Malmö, Sweden.;Aarhus Univ, Dept Dent & Oral Hlth, Sect Orofacial Pain & Jaw Funct, Aarhus, Denmark.
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- Pigg, Maria (författare)
- Malmö universitet,Odontologiska fakulteten (OD),Foresight,Scandinavian Ctr Orofacial Neurosci, Aarhus, Denmark.;Scandinavian Ctr Orofacial Neurosci, Malmö, Sweden.
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- Vase, Lene (författare)
- Aarhus Univ, Sch Business & Social Sci, Dept Psychol & Behav Sci, Aarhus, Denmark.
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Aarhus Univ, Sch Business & Social Sci, Dept Psychol & Behav Sci, Aarhus, Denmark;Tokushima Univ, Dept Prevent Med, Grad Sch Biomed Sci, Tokushima, Japan.;Tokushima Univ, Dept Prevent Med, Grad Sch Biomed Sci, 3-18-15 Kuramoto Cho, Tokushima 7708503, Japan. Aarhus Univ, Sch Business & Social Sci, Dept Psychol & Behav Sci, Aarhus, Denmark. (creator_code:org_t)
- 2023-01-24
- 2023
- Engelska.
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Ingår i: Journal of Oral Rehabilitation. - : John Wiley & Sons. - 1365-2842 .- 0305-182X. ; 50:4, s. 332-342
- Relaterad länk:
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https://doi.org/10.1...
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https://mau.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BackgroundThe nocebo response refers to the phenomenon where non-specific factors, including negative verbal suggestion and treatment expectations, cause adverse events (AE) following a placebo treatment. Non-specific factors are also likely to influence AE occurrence following administration of active pharmacological treatments. ObjectiveThis meta-analysis aimed to estimate the nocebo response in dentistry by assessing the AEs prevalence in placebo- and active arms of randomised controlled trials (RCTs) assessing analgesic treatment following third molar (M3) surgery. MethodsA systematic search was performed in PubMed, Embase, Scopus, Web of Science and the Cochrane Central Register of Controlled Trials. Eligible studies had to report the number of patients experiencing at least one drug-related AE (patients with AE >= 1) separately for the active and placebo arms. The proportion of patients with AE >= 1 and drug-related dropouts were pooled, and risk differences (RDs) between patients in the placebo- and active arm were calculated. ResultsIn 50 independent RCTs of 47 identified articles, the pooled rates of patients with AE >= 1 were 22.8% in the placebo arm and 20.6% in the active arm. The pooled rates of drug-related dropout were 0.24% in the placebo arm and 0.08% in the active arm. There were no significant RDs in patients with AE >= 1 and drug-related dropouts. ConclusionThese results show that patients in the placebo arm reported AEs to the same extent as patients receiving active treatment, suggesting that most AEs in analgesic medication following M3 surgery may be attributed to the nocebo phenomenon.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Nyckelord
- analgesics
- long term adverse effects
- nocebo effect
- oral surgery
- pain
- third molar
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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