Dental Implants in Patients Receiving Chemotherapy: A Meta-Analysis

Dental Implants in Patients Receiving Chemotherapy : A Meta-Analysis

Purpose: To test the null hypothesis of no difference in the implant failure rates, postoperative infection, and marginal bone loss for patients being rehabilitated by dental implants and being versus not being submitted to chemotherapy, against the alternative hypothesis of a difference. Methods: An electronic search without time or language restrictions was undertaken in May 2014 in PubMed/MEDLINE, Web of Science, Cochrane Oral Health Group Trials Register plus hand-searching. Eligibility criteria included clinical human studies, either randomized or not. Results: Nine publications were included. The results suggested that the insertion of dental implants in patients submitted or not submitted to chemotherapy did not affect the implant failure rates (risk ratio 1.02, 95% confidence interval 0.56-1.85; P = 0.95). Because of lack of enough information, meta-analyses for the outcomes "postoperative infection" and "marginal bone loss" were not performed. Conclusion: These results cannot suggest that the insertion of dental implants in patients submitted to chemotherapy may or may not affect the implant failure rates, because of a limited number of published studies, most of them characterized by a low level of specificity and dealing with a limited number of cases without a control group. The reliability and validity of the data collected and the potential for biases and confounding factors are some of the shortcomings of the present study.

Albrektsson, TomasGothenburg University,Göteborgs universitet,Malmö högskola,Odontologiska fakulteten (OD),Department of Biomaterials, Göteborg University, Göteborg, Sweden,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials(Swepub:gu)xalbto (author)
Wennerberg, AnnMalmö högskola,Odontologiska fakulteten (OD)(Swepub:gu)xwenan (author)
Malmö högskolaOdontologiska fakulteten (OD) (creator_code:org_t)

In:Implant Dentistry: Lippincott Williams & Wilkins25:2, s. 261-2711056-61631538-2982

By the author/editor: Chrcanovic, Brun ...; Albrektsson, Tom ...; Wennerberg, Ann

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Dentistry

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