Lactobacillus reuteri supplements do not affect salivary IgA or cytokine levels in healthy subjects: A randomized, double-blind placebo-controlled, cross-over trial

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Jørgensen, Mette RoseDepartment of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (författare)

Lactobacillus reuteri supplements do not affect salivary IgA or cytokine levels in healthy subjects : A randomized, double-blind placebo-controlled, cross-over trial

Artikel/kapitelEngelska2016

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2016-04-22
Informa Healthcare,2016
printrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:mau-6192
https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-6192URI
https://doi.org/10.3109/00016357.2016.1169439DOI

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Språk:engelska
Sammanfattning på:engelska

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Objectives: To evaluate the effect of daily ingestion of probiotic lactobacilli on the levels of secretory IgA (sIgA) and selected cytokines in whole saliva of healthy young adults. Materials and methods: The study group consisted of 47 healthy adults (18-32 years) who volunteered for a randomized, double-blind, placebo-controlled, cross-over trial after informed consent. During intervention, the subjects ingested two lozenges per day containing two strains of the probiotic bacterium Lactobacillus reuteri (DSM 17938 and ATCC PTA 5289) or placebo lozenges. The intervention and wash-out periods were 3 weeks. Saliva samples were collected at baseline, immediately after each intervention period and 3 weeks post-intervention. ELISA was used to measure sIgA and luminex technology was used to measure the interleukins (IL)-1, IL-6, IL-8 and IL-10. For statistical analyses a mixed ANOVA model was employed to calculate changes in the salivary outcome variables Results: Forty-one subjects completed the study and reported a good compliance. No significant differences in the concentrations of salivary sIgA or cytokines were recorded between the L. reuteri and placebo interventions or between baseline and 3 weeks post-intervention levels. No side- or adverse effects were reported Conclusions: Supplementation with two strains of the probiotic L. reuteri did not affect sIgA or cytokine levels in whole saliva in healthy young adults. The results thereby indicate that daily oral supplementation with L. reuteri do not seem to modulate the salivary oral immune response in healthy young subjects

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Odontologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Dentistry hsv//eng
immunoglobulins
interleukins
probiotics
clinical studies

Biuppslag (personer, institutioner, konferenser, titlar ...)

Keller, Mette KirstineDepartment of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (författare)
Kragelund, CamillaDepartment of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (författare)
Hamberg, KristinaMalmö högskola,Odontologiska fakulteten (OD)(Swepub:mau)odkrha (författare)
Ericson, DanMalmö högskola,Odontologiska fakulteten (OD)(Swepub:mau)oddaer (författare)
Nielsen, Claus HenrikDepartment of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Institute for Inflammation Research, Department of Rheumatology and Spine Disease, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark (författare)
Twetman, SvanteDepartment of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (författare)
Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkOdontologiska fakulteten (OD) (creator_code:org_t)

Sammanhörande titlar

Ingår i:Acta Odontologica Scandinavica: Informa Healthcare74:5, s. 399-4040001-63571502-3850

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