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Water Sorption and ...
Water Sorption and Structural Properties of Human Airway Mucus in Health and Muco-Obstructive Diseases.
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- Kelly, Susyn J (författare)
- Fisher & Paykel Healthcare Ltd., 15 Maurice Paykel Place, East Tamaki, Auckland NZ-2013, New Zealand; Department of Clinical Sciences, Ross University of Veterinary Medicine, Basseterre KN-0101, Saint Kitts and Nevis
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- Genevskiy, Vladislav (författare)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces
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- Björklund, Sebastian (författare)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces
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- Gonzalez-Martinez, Juan F (författare)
- Department of Applied Physics, Universidad Politécnica de Cartagena, Cartagena 30202, Spain
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- Poeschke, Lara (författare)
- Evang. Kliniken Essen-Mitte GmbH, Essen DE-45136, Germany
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- Schröder, Maik (författare)
- Evang. Kliniken Essen-Mitte GmbH, Essen DE-45136, Germany
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- Nilius, Georg (författare)
- Evang. Kliniken Essen-Mitte GmbH, Essen DE-45136, Germany; Universität Witten/Herdecke, Witten DE-58455, Germany
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- Tatkov, Stanislav (författare)
- Fisher & Paykel Healthcare Ltd., 15 Maurice Paykel Place, East Tamaki, Auckland NZ-2013, New Zealand
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- Kocherbitov, Vitaly (författare)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces
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Fisher & Paykel Healthcare Ltd, 15 Maurice Paykel Place, East Tamaki, Auckland NZ-2013, New Zealand; Department of Clinical Sciences, Ross University of Veterinary Medicine, Basseterre KN-0101, Saint Kitts and Nevis Institutionen för biomedicinsk vetenskap (BMV) (creator_code:org_t)
- American Chemical Society (ACS), 2024
- 2024
- Engelska.
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Ingår i: Biomacromolecules. - : American Chemical Society (ACS). - 1525-7797 .- 1526-4602. ; 25:3, s. 1578-1591
- Relaterad länk:
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https://doi.org/10.1...
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https://mau.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Muco-obstructive diseases change airway mucus properties, impairing mucociliary transport and increasing the likelihood of infections. To investigate the sorption properties and nanostructures of mucus in health and disease, we investigated mucus samples from patients and cell cultures (cc) from healthy, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF) airways. Atomic force microscopy (AFM) revealed mucin monomers with typical barbell structures, where the globule to spacer volume ratio was the highest for CF mucin. Accordingly, synchrotron small-angle X-ray scattering (SAXS) revealed more pronounced scattering from CF mucin globules and suggested shorter carbohydrate side chains in CF mucin and longer side chains in COPD mucin. Quartz crystal microbalance with dissipation (QCM-D) analysis presented water sorption isotherms of the three types of human airway mucus, where, at high relative humidity, COPD mucus had the highest water content compared to cc-CF and healthy airway mucus (HAM). The higher hydration of the COPD mucus is consistent with the observation of longer side chains of the COPD mucins. At low humidity, no dehydration-induced glass transition was observed in healthy and diseased mucus, suggesting mucus remained in a rubbery state. However, in dialyzed cc-HAM, a sorption-desorption hysteresis (typically observed in the glassy state) appeared, suggesting that small molecules present in mucus suppress the glass transition.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
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- ref (ämneskategori)
- art (ämneskategori)
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