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Salivary microbial ...
Salivary microbial profiles in relation to age, periodontal, and systemic diseases
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- Lira-Junior, Ronaldo (författare)
- Karolinska Institutet
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- Åkerman, Sigvard (författare)
- Malmö universitet,Odontologiska fakulteten (OD)
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- Klinge, Björn (författare)
- Malmö universitet,Odontologiska fakulteten (OD),Karolinska Institutet, Department of Dental Medicine, Division of Oral Diseases, Stockholm, Sweden
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- Boström, Elisabeth A. (författare)
- Karolinska Institutet
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- Gustafsson, Anders (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2018-03-14
- 2018
- Engelska.
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Ingår i: PLOS ONE. - : Public Library of Science. - 1932-6203. ; 13:3
- Relaterad länk:
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https://doi.org/10.1...
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https://journals.plo...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background Analysis of saliva is emerging as a promising tool to diagnose and monitor diseases which makes determination of the salivary microbial profile in different scenarios essential. Objective To evaluate the effects of age, periodontal disease, sex, smoking, and medical conditions on the salivary microbial profile. Design A randomly selected sample of 441 individuals was enrolled (51% women; mean age 48.5 +/- 16.8). Participants answered a health questionnaire and underwent an oral examination. Stimulated saliva was collected and the counts of 41 bacteria were determined by checkerboard DNA-DNA hybridization. Results Elderly participants (>64 years old) presented a significant increase in 24 out of 41 bacterial species compared to adults (<= 64 years old). Eubacterium nodatum, Porphyromonas gingivalis, and Tannerella forsythia were significantly higher in participants with generalized bone loss compared to without. Males and non-smokers had higher bacteria counts in saliva. Individuals having mental disorders or muscle and joint diseases showed significantly altered microbial profiles whereas small or no differences were found for subjects with high blood pressure, heart disease, previous heart surgery, bowel disease, tumors, or diabetes. Conclusion Age, periodontal status, sex, smoking, and certain medical conditions namely, mental disorders and muscle and joint diseases, might affect the microbial profile in saliva.
Nyckelord
- Multidisciplinary Sciences
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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