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Colony stimulating ...
Colony stimulating factor-1 in saliva in relation to age, smoking, and oral and systemic diseases
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- Lira-Junior, Ronaldo (författare)
- Karolinska Institutet, Department of Dental Medicine, Division of Periodontology, Stockholm, Sweden; Rio de Janeiro State University, Faculty of Odontology, Department of Periodontology, Rio de Janeiro, Brazil
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- Åkerman, Sigvard (författare)
- Malmö högskola,Odontologiska fakulteten (OD)
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- Gustafsson, Anders (författare)
- Karolinska Institutet
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- Klinge, Björn (författare)
- Malmö högskola,Odontologiska fakulteten (OD),Karolinska Institutet, Department of Dental Medicine, Division of Periodontology, Stockholm, Sweden
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- Boström, Elisabeth A. (författare)
- Karolinska Institutet
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Lira, R Jr (författare)
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(creator_code:org_t)
- 2017-08-04
- 2017
- Engelska.
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Ingår i: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 7
- Relaterad länk:
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https://www.nature.c...
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https://mau.diva-por... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Colony stimulating factor (CSF)-1 is a growth factor that stimulates the survival, proliferation and differentiation of mononuclear phagocytes, which has been implicated in several inflammatory diseases. This study evaluated the possible influence of age, sex, smoking, periodontitis, caries, and several systemic conditions on salivary levels of CSF-1. Four-hundred and forty-one individuals were enrolled in this study. All participants answered a health questionnaire and underwent a comprehensive oral examination. Stimulated saliva was collected and CSF-1 levels were analysed by enzyme-linked immunosorbent assay. Salivary levels of CSF-1 were significantly increased in participants over 64 years old and in non-smoking individuals, whereas no difference was observed between men and women. Individuals having periodontitis and manifest caries had significantly higher levels of CSF-1. Participants with muscle and joint disease exhibited increased CSF-1 levels as compared to those without. Age, smoking, percentage of pockets >= 4 mm, number of manifest caries lesions, and presence of tumor were associated with CSF-1 levels. Salivary levels of CSF-1 are associated with age, smoking, periodontitis, manifest caries, and the presence of muscle and joint diseases and tumors. CSF-1 might be a promising biomarker candidate in saliva of both local and systemic conditions that needs further investigation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Nyckelord
- Multidisciplinary Sciences
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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