Effect of Experimental Periodontal Ligament Pain on Gingival Somatosensory Sensitivity

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Lu, ShengyiOral Implantology Center Beijing Stomatological Hospital Capital Medical University, Beijing, China; Section of Orofacial Pain and Jaw Function Department of Dentistry, HEALTH Aarhus University, Aarhus, Denmark; Department of Dentistry, HEALTH Aarhus University, Aarhus, Denmark (författare)

Effect of Experimental Periodontal Ligament Pain on Gingival Somatosensory Sensitivity

Artikel/kapitelEngelska2017

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Quintessence,2017
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LIBRIS-ID:oai:DiVA.org:mau-6958
https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-6958URI
https://doi.org/10.11607/ofph.1765DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:135172983URI

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Språk:engelska
Sammanfattning på:engelska

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Aims: To use a randomized, blinded, crossover design to evaluate the possible heterotopic effects of experimental periodontal ligament pain on adjacent gingival somatosensory sensitivity. Methods: A total of 12 healthy volunteers (8 female, 4 male; mean age standard error in means (SEM): 28 1 years) participated in two randomized experimental quantitative sensory testing (QST) sessions, one in which capsaicin (experimental) was injected into the periodontal ligament and one in which isotonic saline (control) was injected. A total of 13 standardized QST measures were obtained on the buccal attached gingiva of a maxillary central incisor before, immediately after, and 30 minutes after injection of 30 mu L of 5% capsaicin or isotonic saline into the periodontal ligament of the same incisor. The injection-evoked pain was evaluated on a 0-10 numeric rating scale (NRS). QST data were analyzed with two-way repeated measurement analysis of variance. Results: Capsaicin injected into the periodontal ligament evoked moderate levels of pain (mean peak NRS SEM: capsaicin: 5.5.7; control: 0.6 0.5 [P < .001]). Capsaicin injected into the periodontal ligament significantly modulated gingival somatosensory sensitivity: increased sensitivity to warmth and painful heat stimuli occurred immediately and 30 minutes after the injection (P < .025), whereas decreased sensitivity to both tactile and painful mechanical stimuli (P < .011) occurred immediately after the injection and to painful mechanical stimuli only after 30 minutes (P = .016). No somatosensory changes were detected following the injection of isotonic saline (P > .050). Conclusion: Capsaicin injected into the periodontal ligament caused gain of heterotopic somatosensory sensitivity toward warmth and painful heat stimuli as well as reduction in mechanical sensitivity of the gingiva adjacent to the injected tooth. These findings may have implications for interpretation of somatosensory functions in patients with chronic intraoral pain, where gingival somatosensory profiles similar to those detected after capsaicin injection in the present study may be interpreted as signs of nerve damage.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Odontologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Dentistry hsv//eng
capsaicin
intraoral QST
pain mechanisms
periodontal ligament
somatosensory

Biuppslag (personer, institutioner, konferenser, titlar ...)

Svensson, PeterKarolinska Institutet (författare)
Zhang, ZhentingOral Implantology Center Beijing Stomatological Hospital Capital Medical University, Beijing, China (författare)
List, ThomasMalmö högskola,Odontologiska fakulteten (OD),Scandinavian Center for Orofacial Neurosciences (SCON); Department of Rehabilitation Medicine, Skåne University Hospital, Lund, Sweden(Swepub:mau)odthli (författare)
Baad-Hansen, LeneSection of Orofacial Pain and Jaw Function Department of Dentistry, HEALTH Aarhus University, Aarhus, Denmark; Scandinavian Center for Orofacial Neurosciences (SCON) (författare)
Karolinska InstitutetOral Implantology Center Beijing Stomatological Hospital Capital Medical University, Beijing, China; Section of Orofacial Pain and Jaw Function Department of Dentistry, HEALTH Aarhus University, Aarhus, Denmark; Department of Dentistry, HEALTH Aarhus University, Aarhus, Denmark (creator_code:org_t)

Sammanhörande titlar

Ingår i:JOURNAL OF ORAL & FACIAL PAIN AND HEADACHE: Quintessence31:1, s. 72-792333-0384

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Av författaren/redakt...: Lu, Shengyi; Svensson, Peter; Zhang, Zhenting; List, Thomas; Baad-Hansen, Len ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Odontologi

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Av lärosätet: Malmö universitet; Karolinska Institutet

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