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- Holm, L.Medical Product Agency, Uppsala, Sweden (författare)
Influence of age, sex and seriousness on reporting of adverse drug reactions in Sweden
- Artikel/kapitelEngelska2017
Förlag, utgivningsår, omfång ...
- 2017-01-10
- John Wiley and Sons Ltd,2017
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Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:mdh-35172
- https://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-35172URI
- https://doi.org/10.1002/pds.4155DOI
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- Språk:engelska
- Sammanfattning på:engelska
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- Purpose: To investigate how reporting of adverse drug reactions (ADRs) among adults in Sweden is associated to age and sex, in addition to seriousness of the reaction and drug utilisation. Methods: Individual case safety reports (ICSRs) reported by healthcare professionals to the national pharmacovigilance database 2008–2011 were related to defined daily dose (DDD) in the Swedish Prescribed Drug Register (SPDR) for individual’s ≥20 years. Data were stratified into five age groups. Crude and adjusted (by age standardisation of prescribed drugs) reporting rate (RR) and reporting rate ratio was evaluated as well as impact of sex-dependent drugs. Results: Based on 9898 included ICSRs, the crude results show that overall RR was almost similar for both serious and non-serious reports and indicates highest RR in the youngest age group. Women had higher rates than men, with predominance for non-serious reports, contrary to men who had a higher RR of serious ones. Standardisation led partly to the same result, but age-related distribution was adjusted, with highest overall RR in the oldest age groups. Sex-dependent drugs had marginal impact on the results. Conclusion: Age and sex have impact on spontaneous reporting of ADRs. After adjusting for dispensed drugs and by standardisation of age-related differences in prescribed drugs, results indicate that healthcare professionals more frequently reported ADRs for the oldest individuals and for women. Serious reports were more frequently reported for men.
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- Ekman, E.Skåne University Hospital, Lund, Sweden (författare)
- Jorsäter Blomgren, KerstinMälardalens högskola,Hälsa och välfärd(Swepub:mdh)kjn02 (författare)
- Medical Product Agency, Uppsala, SwedenSkåne University Hospital, Lund, Sweden (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Pharmacoepidemiology and Drug Safety: John Wiley and Sons Ltd26:3, s. 335-3431053-85691099-1557
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- Pharmacoepidemiology and Drug Safety (Sök värdpublikationen i LIBRIS)
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