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  • Lindstrom, SaraUmeå universitet,Onkologi,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Dept Med Epidemiol & Biostat, S-17177 Stockholm, Sweden.;Umea Univ, Dept Radiat Sci, Umea, Sweden. (author)

Genetic variation in the upstream region of ERG and prostate cancer

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • 2009-02-10
  • SPRINGER,2009
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:mdh-40700
  • https://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-40700URI
  • https://doi.org/10.1007/s10552-009-9305-3DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-25816URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:119188821URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • A considerable fraction of prostate cancers harbor a gene fusion between the androgen-regulated TMPRSS2 and ERG, one of the most frequently over-expressed proto-oncogenes in prostate cancer. Here, we investigated if inherited genetic variation upstream of ERG alters prostate cancer risk and survival. We genotyped 21 haplotype tagging SNPs (htSNPs) covering 123 kb of 5'UTR DNA including exon 3 of ERG in 2,760 incident prostate cancer cases and 1,647 controls from a population-based Swedish case-control study (CAPS). Individual SNPs and haplotypes were tested for association with prostate cancer risk and survival. One haplotype-'CTCGTATG' located 100 kb upstream of ERG-was associated with lethal prostate cancer (HR, 1.36; 95% CI, 1.2-1.9, p = 0.006). Carriers of the variant 'T' allele of rs2836626 were diagnosed with higher TNM-stage (p = 0.009) and had an increased risk of prostate cancer-specific death (HR = 1.3; 95% CI, 1.1-1.7, p = 0.009). However, this association did not remain statistically significant after adjusting for multiple testing. We found overall no association between ERG variation and prostate cancer risk. Genetic variation upstream of ERG may alter prostate cancer stage and ultimately prostate cancer-specific death but it is unlikely that it plays a role in prostate cancer development.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Adami, Hans-OlovKarolinska Institutet (author)
  • Bälter, KatarinaKarolinska Institutet(Swepub:mdh)kbr01 (author)
  • Xu, JianfengWake Forest Univ, Bowman Gray Sch Med, Ctr Human Genom, Winston Salem, NC USA.,Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, USA (author)
  • Zheng, S. LillyWake Forest Univ, Bowman Gray Sch Med, Ctr Human Genom, Winston Salem, NC USA.,Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, USA (author)
  • Sun, JielinWake Forest Univ, Bowman Gray Sch Med, Ctr Human Genom, Winston Salem, NC USA.,Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, USA (author)
  • Stattin, PärUmeå universitet,Urologi och andrologi,Umea Univ, Dept Surg & Perioperat Sci, Umea, Sweden.(Swepub:umu)past0003 (author)
  • Gronberg, HenrikKarolinska Institutet (author)
  • Wiklund, FredrikKarolinska Institutet (author)
  • Umeå universitetOnkologi (creator_code:org_t)

Related titles

  • In:Cancer Causes and Control: SPRINGER20:7, s. 1173-11800957-52431573-7225

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