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  • Lindstrom, SaraUmeå universitet,Onkologi (author)

Inherited variation in hormone-regulating genes and prostate cancer survival

  • Article/chapterEnglish2007

Publisher, publication year, extent ...

  • Umea Univ, Dept Radiat Sci Oncol, SE-90185 Umea, Sweden. Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, Umea, Sweden. Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. Wake Forest Univ, Sch Med, Ctr Human Genom, Winston Salem, NC 27109 USA.AMER ASSOC CANCER RESEARCH,2007
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:mdh-40710
  • https://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-40710URI
  • https://doi.org/10.1158/1078-0432.CCR-07-0669DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2505URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:115870696URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Purpose: Hormonal manipulation is the mainstay treatment of prostate cancer, notably in advanced stages. Despite initial favorably response, the cancer eventually develops hormone resistance resulting in disease progression and death. However, little is known about genetic determinants of disease progression and prostate cancer-specific death. Experimental Design: We analyzed a population-based cohort comprising 2,761 men diagnosed with prostate cancer from March 2001 to October 2003 and with complete follow-up through July 2006. During a median follow-up time of 3.8 years, a total of 300 men had died from prostate cancer. We genotyped 23 haplotype tagging single nucleoticle polymorphisms in the genes AR, CYP17, and SRD5A2 and used Cox proportional hazards analyses to quantify associations between genotype and risk of dying from prostate cancer. Results: The variant 'A': allele of an AR promoter single nucleoticle polymorphism, rs17302090, was borderline associated with a 50% increased risk of dying from prostate cancer (95% confidence interval, 1.0-2.3; P = 0.07). This finding was more pronounced in patients who received hormonal therapy as primary treatment at diagnosis (hazard ratio, 19; 95% confidence interval, 1.3-2.9; P = 0.007). We did not identify any associations between CYP17 or SRD5A2 variation and prostate cancer-specific death. Conclusions: Our results suggest that inherited genetic variation in the androgen receptor gene affects hormonal treatment response and ultimately prostate cancer death.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Adami, Hans-OlovKarolinska Institutet (author)
  • Bälter, Katarina AugustssonKarolinska Institutet(Swepub:mdh)kbr01 (author)
  • Xu, Jianfeng (author)
  • Zheng, S. Lilly (author)
  • Stattin, PaerUmeå universitet,Urologi och andrologi (author)
  • Gronberg, HenrikKarolinska Institutet (author)
  • Wiklund, FredrikKarolinska Institutet (author)
  • Umeå universitetOnkologi (creator_code:org_t)

Related titles

  • In:Clinical Cancer ResearchUmea Univ, Dept Radiat Sci Oncol, SE-90185 Umea, Sweden. Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, Umea, Sweden. Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. Wake Forest Univ, Sch Med, Ctr Human Genom, Winston Salem, NC 27109 USA. : AMER ASSOC CANCER RESEARCH13:17, s. 5156-51611078-04321557-3265

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