Associations Between MAOA-uVNTR Genotype, Maltreatment, MAOA Methylation, and Alcohol Consumption in Young Adult Males

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Bendre, MeghaUppsala universitet,Neuropsykofarmakologi,Centrum för klinisk forskning, Västerås (författare)

Associations Between MAOA-uVNTR Genotype, Maltreatment, MAOA Methylation, and Alcohol Consumption in Young Adult Males

Artikel/kapitelEngelska2018

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2018-01-31
WILEY,2018
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LIBRIS-ID:oai:DiVA.org:mdh-51985
https://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-51985URI
https://doi.org/10.1111/acer.13578DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-351264URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:137729335URI

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Språk:engelska
Sammanfattning på:engelska

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BackgroundEpigenetic mechanisms are candidate moderators of the effect of maltreatment on brain and behavior. Interactions between maltreatment and the monoamine oxidase A upstream variable number tandem repeat genotype (MAOA-uVNTR) are associated with alcohol-related problems. However, presently it is not known whether DNA methylation moderates this association. The study focused on 53 young adult males and aimed to determine whether MAOA methylation moderated the association of alcohol-related problems with the interaction of MAOA-uVNTR and maltreatment, and whether alcohol consumption moderated the association of MAOA methylation with the interaction of MAOA-uVNTR and maltreatment. MethodsMAOA-uVNTR genotypes with 3 and > 3 repeats were categorized as short (S) and long (L), respectively. Data on maltreatment were obtained retrospectively, using self-reported questionnaires. DNA methylation of 16 candidate CpGs within part of the MAOA first exon and intron was assessed and grouped based on principal component analyses. Alcohol-related problems were assessed using the Alcohol Use Disorders Identification Test (AUDIT). Alcohol consumption was measured using AUDIT-C. Moderation effects were assessed and probed using the moderated moderation model and Johnson-Neyman's method, respectively. ResultsCarriers of the S allele, who experienced maltreatment and displayed lower Component 1 (mean of CpGs 13-16 in the first intron) MAOA methylation levels, reported higher AUDIT score in contrast to L-allele carriers. Carriers of the S allele, who reported higher AUDIT-C score and experienced maltreatment, displayed lower Component 3 (mean of CpGs 2-6 in the first exon) MAOA methylation levels than L-allele carriers. ConclusionsIntronic methylation moderated the association of alcohol-related problems with the interaction of MAOA-uVNTR and maltreatment. Alcohol consumption moderated the association of exonic methylation with the interaction of MAOA-uVNTR and maltreatment. These results suggest that epigenetic factors as well as genotype and maltreatment play a role in the development of alcohol misuse among young adult males.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng
Alcohol
DNA Methylation
Gene by Environment
MAOA-
uVNTR
Maltreatment

Biuppslag (personer, institutioner, konferenser, titlar ...)

Comasco, Erika,1982-Uppsala universitet,Neuropsykofarmakologi(Swepub:uu)erico267 (författare)
Checknita, DaveUppsala universitet,Centrum för klinisk forskning, Västerås,Institutionen för neurovetenskap,Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden(Swepub:uu)davch991 (författare)
Tiihonen, JariKarolinska Institutet (författare)
Hodgins, SheilaghUniv Montreal, Inst Univ Sante Mentale Montreal, Montreal, PQ, Canada. (författare)
Nilsson, Kent W.Uppsala universitet,Centrum för klinisk forskning, Västerås(Swepub:uu)kenil169 (författare)
Uppsala universitetNeuropsykofarmakologi (creator_code:org_t)

Sammanhörande titlar

Ingår i:Alcoholism: WILEY42:3, s. 508-5190145-60081530-0277

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Av författaren/redakt...: Bendre, Megha; Comasco, Erika, ...; Checknita, Dave; Tiihonen, Jari; Hodgins, Sheilag ...; Nilsson, Kent W.

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Psykiatri

Artiklar i publikationen: Alcoholism

Av lärosätet: Mälardalens universitet; Uppsala universitet; Karolinska Institutet

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