Three-way interaction effect of 5-HTTLPR, BDNF Val66Met, and childhood adversity on depression: A replication study

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Comasco, ErikaUppsala universitet,Neuropsykofarmakologi,Uppsala Univ, Dept Neurosci, Pharmacol Unit, BMC, S-75124 Uppsala, Sweden. (författare)

Three-way interaction effect of 5-HTTLPR, BDNF Val66Met, and childhood adversity on depression : A replication study

Artikel/kapitelEngelska2013

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ELSEVIER,2013
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LIBRIS-ID:oai:DiVA.org:mdh-52023
https://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-52023URI
https://doi.org/10.1016/j.euroneuro.2013.01.010DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-200313URI

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Språk:engelska
Sammanfattning på:engelska

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Both the serotonin transporter linked promoter region (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms have been shown to interact with unfavourable environment in relation to depression symptoms and to depression diagnosis. Several attempts have been made to study a three-way interaction effect of these factors on depression, however with contradictory results. We aimed to test the hypothesis of a three-way interaction effect and to attempt at replication in an independent population-based sample. Family maltreatment, sexual abuse and depression were self-reported by an adolescent population-based cohort (N=1393) from the county of Vastmanland, Sweden. DNA was isolated from saliva, and used for genotyping of the 5-HTTLPR and BDNF Val66Met polymorphisms. Neither 5-HTTLPR or BDNF genotypes separately, nor in interaction with each other had any relation to depression, however in an environment adjusted model a two-way interaction and a three-way interaction effect was found. Both 5-HTTLPR and BDNF Val66Met interacted with unfavourable environment in relation to depressive symptoms (Adj R-2=0.19). Depressive symptoms and depression were more common among carriers of either the ss/sl+Val/Val or the ll+Met genotypes in the presence of early-life adversities. This three-way effect was more pronounced among girls. The current study, with a virtually similar set-up compared to previous studies, can partially confirm previous findings and their generalizability. The study also shows the importance of genetic plasticity in individuals with different environmental exposure, for different phenotypic expression.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
Adolescents
Brain-derived neurotrophic factor
Depression
Maltreatment
Serotonin transporter
Sexual abuse

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Åslund, CeciliaUppsala universitet,Centrum för klinisk forskning, Västerås,Uppsala Univ, Cty Hosp, Clin Res Ctr, S-72189 Vasteras, Sweden.(Swepub:uu)cecas802 (författare)
Oreland, LarsUppsala universitet,Neuropsykofarmakologi,Uppsala Univ, Dept Neurosci, Pharmacol Unit, BMC, S-75124 Uppsala, Sweden.(Swepub:uu)larsore (författare)
Nilsson, Kent W.Uppsala universitet,Centrum för klinisk forskning, Västerås,Uppsala Univ, Cty Hosp, Clin Res Ctr, S-72189 Vasteras, Sweden.(Swepub:uu)kenil169 (författare)
Uppsala universitetNeuropsykofarmakologi (creator_code:org_t)

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Ingår i:European Neuropsychopharmacology: ELSEVIER23:10, s. 1300-13060924-977X1873-7862

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Av författaren/redakt...: Comasco, Erika; Åslund, Cecilia; Oreland, Lars; Nilsson, Kent W.

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin

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Av lärosätet: Mälardalens universitet; Uppsala universitet

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