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Association of Sarc...
Association of Sarcopenia and Its Defining Components with the Degree of Cognitive Impairment in a Memory Clinic Population
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- Larsson, L. E. (författare)
- Gymnastik- och idrottshögskolan,Institutionen för fysisk aktivitet och hälsa,Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden,Master student
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- Wang, Rui (författare)
- Gymnastik- och idrottshögskolan,Institutionen för fysisk aktivitet och hälsa,Department of Neurobiology, Division of Clinical Geriatrics, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.,Fysisk aktivitet och hjärnhälsa
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- Cederholm, Tommy (författare)
- Uppsala universitet,Klinisk nutrition och metabolism,Karolinska Univ Hosp, Theme Inflammat & Aging, Stockholm, Sweden.,Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden.; Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden.
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- Wiggenraad, F. (författare)
- Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden.; Department of Neurobiology, Division of Clinical Geriatrics, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.,Karolinska Univ Hosp, Theme Inflammat & Aging, Stockholm, Sweden.;Karolinska Inst, Div Clin Geriatr, Dept Neurobiol, Care Sci & Soc, Stockholm, Sweden.
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- Rydén, M. (författare)
- Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden.,Karolinska Univ Hosp, Theme Inflammat & Aging, Stockholm, Sweden.
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- Hagman, G. (författare)
- Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden.; Department of Neurobiology, Division of Clinical Geriatrics, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.,Karolinska Univ Hosp, Theme Inflammat & Aging, Stockholm, Sweden.;Karolinska Inst, Div Clin Geriatr, Dept Neurobiol, Care Sci & Soc, Stockholm, Sweden.
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- Hellénius, M. -L (författare)
- Department of Medicine, Karolinska Institutet, Stockholm, Sweden.,Karolinska Inst, Dept Med, Stockholm, Sweden.
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- Kivipelto, M. (författare)
- Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden.; Department of Neurobiology, Division of Clinical Geriatrics, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.: The Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, London, United Kingdom.,Karolinska Univ Hosp, Theme Inflammat & Aging, Stockholm, Sweden.;Karolinska Inst, Div Clin Geriatr, Dept Neurobiol, Care Sci & Soc, Stockholm, Sweden.;Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.;Imperial Coll London, Ageing Epidemiol Res Unit, Sch Publ Hlth, London, England.
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- Thunborg, Charlotta, 1965- (författare)
- Karolinska Institutet,Mälardalens universitet,Hälsa och välfärd,Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden.; Department of Neurobiology, Division of Clinical Geriatrics, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.; Mälardalen University Department of Health and Welfare, Sweden.; Department of Caring Sciences, Faculty of Health and Occupational Studies, University of Gävle, Sweden.,Karolinska Univ Hosp, Theme Inflammat & Aging, Stockholm, Sweden.;Karolinska Inst, Div Clin Geriatr, Dept Neurobiol, Care Sci & Soc, Stockholm, Sweden.;Mälardalen Univ, Dept Hlth & Welf, Västerås, Sweden.;Univ Gävle, Fac Hlth & Occupat Studies, Dept Caring Sci, Gävle, Sweden.
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(creator_code:org_t)
- IOS Press BV, 2023
- 2023
- Engelska.
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Ingår i: Journal of Alzheimer's Disease. - : IOS Press BV. - 1387-2877 .- 1875-8908. ; 96:2, s. 777-788
- Relaterad länk:
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https://doi.org/10.3...
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https://gih.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Sarcopenia and cognitive impairment are two leading causes of disabilities. Objective: The objective was to examine the prevalence of sarcopenia and investigate the association between sarcopenia diagnostic components (muscle strength, muscle mass, and physical performance) and cognitive impairment in memory clinic patients. Methods: 368 patients were included (age 59.0±7.25 years, women: 58.7%), displaying three clinical phenotypes of cognitive impairments, i.e., subjective cognitive impairment (SCI, 57%), mild cognitive impairment (MCI, 26%), and Alzheimer's disease (AD, 17%). Sarcopenia was defined according to diagnostic algorithm recommended by the European Working Group on Sarcopenia in Older People. Components of sarcopenia were grip strength, bioelectrical impedance analysis, and gait speed. They were further aggregated into a score (0-3 points) by counting the numbers of limited components. Multi-nominal logistic regression was applied. Results: Probable sarcopenia (i.e., reduced grip strength) was observed in 9.6% of the patients, and 3.5% were diagnosed with sarcopenia. Patients with faster gait speed showed less likelihood of MCI (odds ratio [OR]: 0.24, 95% confidence interval [CI]: 0.06-0.90) and AD (OR: 0.12, 95% CI: 0.03-0.60). One or more limited sarcopenia components was associated with worse cognitive function. After adjusting for potential confounders, the association remained significant only for AD (OR 4.29, 95% CI 1.45-11.92). Conclusion: The results indicate a connection between the sarcopenia components and cognitive impairments. Limitations in the sarcopenia measures, especially slow walking speed, were related to poorer cognitive outcomes. More investigationsare required to further verify the causal relationship between sarcopenia and cognitive outcomes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Alzheimer's disease
- body composition
- cognitive function
- gait speed
- hand grip strength
- outpatients
- sarcopenia
- Aged
- Cognitive Dysfunction
- Female
- Hand Strength
- Humans
- Muscle Strength
- Walking Speed
- cognitive defect
- complication
- human
- physiology
- Medicin/Teknik
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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