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- Rezazadeh, M. R.School of Mechanical Engineering, Shiraz University, Shiraz, Iran (author)
A quasi-realistic computational model development and flow field study of the human upper and central airways
- Article/chapterEnglish2024
Publisher, publication year, extent ...
- 2024
- Springer Science and Business Media Deutschland GmbH,2024
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:mdh-66735
- https://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-66735URI
- https://doi.org/10.1007/s11517-024-03117-9DOI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- The impact of drug delivery and particulate matter exposure on the human respiratory tract is influenced by various anatomical and physiological factors, particularly the structure of the respiratory tract and its fluid dynamics. This study employs computational fluid dynamics (CFD) to investigate airflow in two 3D models of the human air conducting zone. The first model uses a combination of CT-scan images and geometrical data from human cadaver to extract the upper and central airways down to the ninth generation, while the second model develops the lung airways from the first Carina to the end of the ninth generation using Kitaoka’s deterministic algorithm. The study examines the differences in geometrical characteristics, airflow rates, velocity, Reynolds number, and pressure drops of both models in the inhalation and exhalation phases for different lobes and generations of the airways. From trachea to the ninth generation, the average air flowrates and Reynolds numbers exponentially decay in both models during inhalation and exhalation. The steady drop is the case for the average air velocity in Kitaoka’s model, while that experiences a maximum in the 3rd or 4th generation in the quasi-realistic model. Besides, it is shown that the flow field remains laminar in the upper and central airways up to the total flow rate of 15 l/min. The results of this work can contribute to the understanding of flow behavior in upper respiratory tract. Graphical Abstract: (Figure presented.)
Subject headings and genre
- TEKNIK OCH TEKNOLOGIER Maskinteknik hsv//swe
- ENGINEERING AND TECHNOLOGY Mechanical Engineering hsv//eng
- Computational fluid dynamics (CFD)
- Inhalation and Exhalation
- Kitaoka’s algorithm
- Lung generations
- Respiratory tract
- Air
- Biological organs
- Computerized tomography
- Drops
- Drug delivery
- Flow fields
- Reynolds number
- Air flow-rate
- Computational fluid dynamic
- Computational modelling
- Kitaokum’s algorithm
- Lung generation
- Model development
- Reynold number
- S-algorithms
- Computational fluid dynamics
Added entries (persons, corporate bodies, meetings, titles ...)
- Dastan, A.Department of Mechanical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran (author)
- Sadrizadeh, SasanMälardalens universitet,Framtidens energi,Department of Civil and Architectural Engineering, KTH University, Stockholm, Sweden(Swepub:mdh)ssh03 (author)
- Abouali, O.School of Mechanical Engineering, Shiraz University, Shiraz, Iran. Department of Civil and Architectural Engineering, KTH University, Stockholm, Sweden (author)
- School of Mechanical Engineering, Shiraz University, Shiraz, IranDepartment of Mechanical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran (creator_code:org_t)
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- In:Medical and Biological Engineering and Computing: Springer Science and Business Media Deutschland GmbH0140-01181741-0444
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